Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway

• Published in: Pharmazie Vol. 68; no. 6; pp. 442 - 448
• Main Authors: Jiang, Yu, Yang, Jingbo, Yang, Chunhui, Meng, Fanmin, Zhou, Yongfeng, Yu, Bo, Khan, Muhammad, Yang, Hong
• Format: Journal Article
• Language: English
• Published: Germany Govi-Verlag 01.06.2013
• Subjects: Animals; Antineoplastic Agents; Apoptosis - drug effects; Blotting, Western; Caspase 3 - physiology; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival - drug effects; DNA Fragmentation; Flow Cytometry; Humans; Indicators and Reagents; Male; Membrane Potential, Mitochondrial - drug effects; Mice; Mitochondria - drug effects; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Reactive Oxygen Species - metabolism; Spleen - cytology; Spleen - drug effects; Tetrazolium Salts; Thiazoles; Vitamin K 3 - analogs & derivatives; Vitamin K 3 - pharmacology

Vitamin K4 (VK4) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It has been reported that several vitamin Ks had inhibitory effects on various cancer cells. However, there is no report about VK4 s anticancer activity. The goal of this study was to inv...