Estradiol-dependent perforin expression by human regulatory T-cells

• Published in: European journal of clinical investigation Vol. 41; no. 4; pp. 357 - 364
• Main Authors: Valor, Larissa, Teijeiro, Roseta, Aristimuño, Carol, Faure, Florence, Alonso, Bárbara, de Andrés, Clara, Tejera, Marta, López-Lazareno, Nieves, Fernández-Cruz, Eduardo, Sánchez-Ramón, Silvia
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2011; Wiley-Blackwell
• Subjects: Adult; Animals; Biological and medical sciences; Estradiol - immunology; Estradiol - metabolism; Estradiol - pharmacology; Female; Flow Cytometry; Forkhead Transcription Factors - immunology; Forkhead Transcription Factors - metabolism; General aspects; Granzymes - immunology; Granzymes - metabolism; Humans; Immune Tolerance; Immunoregulation; intracellular perforin expression; Lymphocyte Activation - immunology; Medical sciences; Mice; Mice, Inbred C57BL; Perforin - immunology; Perforin - metabolism; Pregnancy; Receptors, Antigen, T-Cell - metabolism; regulatory T-cells; Statistics as Topic; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Human; Cytolysin; intracellular perforin expression; Immunoregulation; Estrogen; Immune regulation; regulatory T-cells; Estradiol; Ovarian hormone; Medicine; T-Lymphocyte; Intracellular; Sex steroid hormone; Perforin; Regulatory cell

Eur J Clin Invest 2011; 41 (4): 357–364 Background CD4+CD25+FoxP3+ regulatory T‐cells (nTReg) have been shown to suppress immune responses to autoantigens and to other diverse antigens, this suppression is mainly mediated by a cell contact‐dependent mechanism not yet fully defined. It has been repor...