Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity

• Published in: Pediatric diabetes Vol. 17; no. S22; pp. 8 - 16
• Main Authors: Ilonen, J, Kiviniemi, M, Lempainen, J, Simell, O, Toppari, J, Veijola, R, Knip, M
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01.07.2016
• Subjects: Adult; Autoimmunity; Case-Control Studies; Child; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Female; Genes, MHC Class II; Genetic Predisposition to Disease; genetics; Haplotypes; HLA class II; Humans; islet autoimmunity; Islets of Langerhans - immunology; Male; Risk Assessment; type 1 diabetes; HLA class II; type 1 diabetes; genetics; islet autoimmunity

Objective The HLA‐DR/DQ region remains the major determinant of susceptibility to type 1 diabetes (T1D) despite the more than 50 risk affecting loci outside human leukocyte antigen (HLA) region that have been identified. We aimed at developing a simple risk estimation based on HLA class II genotypin...