Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial

• Published in: Pediatric diabetes Vol. 15; no. 2; pp. 100 - 109
• Main Authors: Giannopoulou, Eleni Z, Puff, Ramona, Beyerlein, Andreas, von Luettichau, Irene, Boerschmann, Heike, Schatz, Desmond, Atkinson, Mark, Haller, Michael J, Egger, Dietmar, Burdach, Stefan, Ziegler, Anette-Gabriele
• Format: Journal Article
• Language: English
• Published: Former Munksgaard John Wiley & Sons A/S 01.03.2014
• Subjects: C-peptide; Child; Child, Preschool; Cord Blood Stem Cell Transplantation - adverse effects; Cord Blood Stem Cell Transplantation - methods; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 1 - therapy; Female; Follow-Up Studies; Humans; Immune System - physiology; Infant; Insulin-Secreting Cells - physiology; Male; regulatory T-lymphocytes; stem cells; Transplantation, Autologous; Treatment Outcome; stem cells; C-peptide; regulatory T-lymphocytes

Background The application of autologous cord blood in children with type 1 diabetes has been found to be safe, but not to preserve beta‐cell function in a previous study, which, however, had not included a control group. Objective To compare the changes of metabolic and immune function over time be...