Genome-wide analysis of histone H3 lysine9 trimethylation by ChIP-seq in peripheral blood mononuclear cells of uremia patients

• Published in: Hemodialysis international Vol. 17; no. 4; pp. 493 - 501
• Main Authors: Sui, Weiguo, He, Huiyan, Yan, Qiang, Chen, Jiejing, Zhang, Ruohan, Dai, Yong
• Format: Journal Article
• Language: English
• Published: Canada Blackwell Publishing Ltd 01.10.2013
• Subjects: Adult; Case-Control Studies; Chip-seq; Chromatin - metabolism; epigenetics; Epigenomics; Female; Genome-Wide Association Study; H3K9me3; Histones - blood; Histones - genetics; Humans; Leukocytes, Mononuclear - metabolism; Male; Renal Dialysis; uremia; Uremia - blood; Uremia - genetics; Uremia - therapy; uremia; Chip-seq; H3K9me3; epigenetics

Treatment of uremia is now dominated by dialysis, in some cases, patients are treated with dialysis for decades, but overall outcomes are disappointing. A number of studies have confirmed the relevance of several experimental insights to the pathogenesis of uremia, but the specific biomarkers of ure...