Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population (中国畲族人群17个糖尿病相关基因位点的遗传变异与心血管风险和糖尿病肾病的相关性)
Background Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes‐related genes/loci, T2DM and diabetic complications in Chinese She subjects. Methods A comprehensive gene‐based association study was conducted us...
Saved in:
| Published in | Journal of diabetes Vol. 5; no. 2; pp. 136 - 145 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Australia
Blackwell Publishing Ltd
01.06.2013
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1753-0393 1753-0407 1753-0407 |
| DOI | 10.1111/1753-0407.12025 |
Cover
| Abstract | Background
Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes‐related genes/loci, T2DM and diabetic complications in Chinese She subjects.
Methods
A comprehensive gene‐based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function.
Results
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)‐β (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05).
Conclusion
Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.
摘要
背景
遗传是决定2型糖尿病发病的重要因素。我们分析了中国畲族人群17个糖尿病相关基因位点的遗传变异与2型糖尿病及并发症之间的相关性。
方法
一项全面的以基因为基础的相关性研究，评估了中国畲族人群的糖耐量正常者（n=1119）、糖耐量异常者（n=1767）和2型糖尿病患者（n=443）的17个基因的单核苷酸多态性（SNP）。以主要的明尼苏达编码异常预测心血管风险，用估算肾小球滤过率评估肾功能。
结果
FTO rs8050136，WFS1 rs10010131，CDKN2A/B rs10811661，KCNJ11 rs5219，CDC123/CAMK1D rs12779790，JAZF1 rs864745，SLC30A8 rs13266634，CDKAL1 rs10946398，和HHEX/IDE rs5015480等9个基因位点变异与2型糖尿病显著相关 （P<0.05）。WFS1 rs10010131，CDKN2A/B rs10811661，CDC123/CAMK1D rs12779790，JAZF1 rs864745，FTO rs8050136和HHEX/IDE rs5015480等的SNP与2型糖尿病和糖耐量异常相关。WFS1 rs10010131，IGF2BP2 rs4402960，CDKAL1 rs10946398，FTO rs8050136，KCNQ1 rs2237897和 ADAMTS9 rs4607103等的风险等位基因与HOMA‐β指数降低显著相关（P<0.05）。校正年龄、性别和体重指数后，JAZF1 rs864745，FTO rs8050136和 HHEX/IDE rs5015480的基因变异与估算肾小球滤过率下降显著相关（P<0.05）。WFS1 rs10010131，CDKN2A/B rs10811661，CDC123/CAMID rs12779790，JAZF1 rs864745，FTO rs80501360， CDKAL1 rs10946398和HHEX/IDE rs5015480 等的基因变异与主要的明尼苏达编码异常显著相关（P< 0.05）。
结论
WFS1，CDKN2A/B，KCNJ11，CDC123/CAMK1D，JAZF1，SLC30A8，FTO，CDKAL1和 HHEX/IDE等的基因变异与中国畲族人群的2型糖尿病显著相关。JAZF1，FTO，CDKAL1和 HHEX/IDE等的基因变异与糖尿病肾病相关。WFS1， CDKN2A/B，CDC123/CAMK1D，JAZF1，FTO，CDKAL1和 HHEX/IDE等的基因变异与心血管风险相关。 |
|---|---|
| AbstractList | Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2DM and diabetic complications in Chinese She subjects.BACKGROUNDGenetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2DM and diabetic complications in Chinese She subjects.A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function.METHODSA comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function.Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-β (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05).RESULTSNine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-β (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05).Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.CONCLUSIONVariants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk. Background Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes‐related genes/loci, T2DM and diabetic complications in Chinese She subjects. Methods A comprehensive gene‐based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function. Results Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)‐β (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05). Conclusion Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk. 摘要 背景 遗传是决定2型糖尿病发病的重要因素。我们分析了中国畲族人群17个糖尿病相关基因位点的遗传变异与2型糖尿病及并发症之间的相关性。 方法 一项全面的以基因为基础的相关性研究，评估了中国畲族人群的糖耐量正常者（n=1119）、糖耐量异常者（n=1767）和2型糖尿病患者（n=443）的17个基因的单核苷酸多态性（SNP）。以主要的明尼苏达编码异常预测心血管风险，用估算肾小球滤过率评估肾功能。 结果 FTO rs8050136，WFS1 rs10010131，CDKN2A/B rs10811661，KCNJ11 rs5219，CDC123/CAMK1D rs12779790，JAZF1 rs864745，SLC30A8 rs13266634，CDKAL1 rs10946398，和HHEX/IDE rs5015480等9个基因位点变异与2型糖尿病显著相关 （P<0.05）。WFS1 rs10010131，CDKN2A/B rs10811661，CDC123/CAMK1D rs12779790，JAZF1 rs864745，FTO rs8050136和HHEX/IDE rs5015480等的SNP与2型糖尿病和糖耐量异常相关。WFS1 rs10010131，IGF2BP2 rs4402960，CDKAL1 rs10946398，FTO rs8050136，KCNQ1 rs2237897和 ADAMTS9 rs4607103等的风险等位基因与HOMA‐β指数降低显著相关（P<0.05）。校正年龄、性别和体重指数后，JAZF1 rs864745，FTO rs8050136和 HHEX/IDE rs5015480的基因变异与估算肾小球滤过率下降显著相关（P<0.05）。WFS1 rs10010131，CDKN2A/B rs10811661，CDC123/CAMID rs12779790，JAZF1 rs864745，FTO rs80501360， CDKAL1 rs10946398和HHEX/IDE rs5015480 等的基因变异与主要的明尼苏达编码异常显著相关（P< 0.05）。 结论 WFS1，CDKN2A/B，KCNJ11，CDC123/CAMK1D，JAZF1，SLC30A8，FTO，CDKAL1和 HHEX/IDE等的基因变异与中国畲族人群的2型糖尿病显著相关。JAZF1，FTO，CDKAL1和 HHEX/IDE等的基因变异与糖尿病肾病相关。WFS1， CDKN2A/B，CDC123/CAMK1D，JAZF1，FTO，CDKAL1和 HHEX/IDE等的基因变异与心血管风险相关。 Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2DM and diabetic complications in Chinese She subjects. A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function. Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-β (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05). Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk. Background Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2DM and diabetic complications in Chinese She subjects. Methods A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n=1119), impaired glucose regulation (n=1767), and T2DM (n=443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function. Results Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P<0.05). Single nucleotide polymorphisms in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA)-[beta] (P<0.05). After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P<0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P<0.05). Conclusion Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk. 2群17ä½2 群n=1119n=17672n=44317SNPè¾¾å¿fè¿[double dagger] FTO rs8050136WFS1 rs10010131CDKN2A/B rs10811661KCNJ11 rs5219CDC123/CAMK1D rs12779790JAZF1 rs864745SLC30A8 rs13266634CDKAL1 rs10946398HHEX/IDE rs50154809ä½2 P<0.05WFS1 rs10010131CDKN2A/B rs10811661CDC123/CAMK1D rs12779790JAZF1 rs864745FTO rs8050136HHEX/IDE rs5015480SNP2WFS1 rs10010131IGF2BP2 rs4402960CDKAL1 rs10946398FTO rs8050136KCNQ1 rs2237897 ADAMTS9 rs4607103ä½HOMA-[beta]ä½ZP<0.05é¾,,ä½"JAZF1 rs864745FTO rs8050136 HHEX/IDE rs5015480è¿[double dagger]P<0.05WFS1 rs10010131CDKN2A/B rs10811661CDC123/CAMID rs12779790JAZF1 rs864745FTO rs80501360 CDKAL1 rs10946398HHEX/IDE rs5015480 è¾¾P< 0.05 WFS1CDKN2A/BKCNJ11CDC123/CAMK1DJAZF1SLC30A8FTOCDKAL1 HHEX/IDE群2JAZF1FTOCDKAL1 HHEX/IDEWFS1 CDKN2A/BCDC123/CAMK1DJAZF1FTOCDKAL1 HHEX/IDEå¿f [PUBLICATION ABSTRACT] |
| Author | Lin, Yinghua Chen, Zichun Lin, Lixiang Lai, Shenghan Chen, Gang Wen, Junping Xu, Yuan Huang, Baoying Lai, Xiaolan Fu, Xianguo Yao, Jin Huang, Huibin |
| Author_xml | – sequence: 1 givenname: Gang surname: Chen fullname: Chen, Gang email: chengang18@yahoo.comwenjunping@medmail.com.cnslai@jhmi.edu organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 2 givenname: Yuan surname: Xu fullname: Xu, Yuan organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 3 givenname: Yinghua surname: Lin fullname: Lin, Yinghua organization: Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China – sequence: 4 givenname: Xiaolan surname: Lai fullname: Lai, Xiaolan organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 5 givenname: Jin surname: Yao fullname: Yao, Jin organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 6 givenname: Baoying surname: Huang fullname: Huang, Baoying organization: Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China – sequence: 7 givenname: Zichun surname: Chen fullname: Chen, Zichun organization: Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China – sequence: 8 givenname: Huibin surname: Huang fullname: Huang, Huibin organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 9 givenname: Xianguo surname: Fu fullname: Fu, Xianguo organization: Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China – sequence: 10 givenname: Lixiang surname: Lin fullname: Lin, Lixiang organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou – sequence: 11 givenname: Shenghan surname: Lai fullname: Lai, Shenghan email: chengang18@yahoo.comwenjunping@medmail.com.cnslai@jhmi.edu organization: Department of Pathology, Radiology, Medicine and Epidemiology, Johns Hopkins Medicine, Maryland, Baltimore, USA – sequence: 12 givenname: Junping surname: Wen fullname: Wen, Junping email: chengang18@yahoo.comwenjunping@medmail.com.cnslai@jhmi.edu organization: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23298195$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkk1v0zAcxgMaYuvgzA1F4jIO2WK7jpvjVqCAqiHEm8TFchOXekuTECeD3kbZbrBJSFBYD2wCCYEEQuxSqr18mWTZvgVuu_WAL3789-95ZMlPQZvwA59r2hVgzgK15gDByDCLJpkF0IT4vDY1nkycaWSjSa0g5ZJpWsSy0EVtEiJol4CNp84V5qUMHMFiEfi6jBO3pQd1_Rn3eSwcfYVFgvmxHMwA0V3Bajzm0oi4x2LuDjk556kAnfmu7rDIFcEKk07isUiPhFwezkc-lefzsBEFIYsbLV34etzgerkhVAbXHygdBqEyDp8yk_Z-Zt39_P2fo85m2u_nB18BSXs_8t0P2e_DvLOed3vZ-m72uZ91t9P9t3n7b761dvKqk-5tZ5sfs7122tvIDl8f76zmv3ZOvmycfPqevXszth-3DwYhW2ujnKPVb9cvaRfqzJP88uk-rT26dfNh-bZRvVe5U56vGgJBhI0aZI6DGLIxg3WoTtwiNWzWMHFwEQIC665VdNwSZwRxUsJ1iDHkjo1MSwlA0LQ2M8oNo-B5wmVMm0I63POYz4NEUoCKBGKLAFuh1_5Dl4Ik8tXrBpQFEAFWSVFXT6mk1uQuDSPRZFGLnv2yAvAIeCE83hrfA5MOSkQHNaGDytBhiejdGwtDoXzGyCdkzF-OfSxaphZBBNMnixX6uPq0eL-ysEht9A-ZI_PM |
| ContentType | Journal Article |
| Copyright | 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine. Copyright © 2013 Ruijin Hospital and Wiley Publishing Asia Pty Ltd |
| Copyright_xml | – notice: 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine – notice: 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine. – notice: Copyright © 2013 Ruijin Hospital and Wiley Publishing Asia Pty Ltd |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM K9. 7X8 |
| DOI | 10.1111/1753-0407.12025 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1753-0407 |
| EndPage | 145 |
| ExternalDocumentID | 2954730341 23298195 JDB12025 ark_67375_WNG_VLZ4QGBN_9 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Natural Science Foundation of Fujian Province funderid: C071002; 2009Y0011; 2011J01127; 2011J06012 – fundername: Natural Science Foundation of China funderid: 81170774; 81270874 |
| GroupedDBID | --- 05W 0R~ 10A 1OC 24P 31~ 3SF 4.4 50Y 52S 52U 52V 53G 5DZ 7X7 8-0 8-1 8FI 8FJ A00 AAESR AAEVG AAHHS AAONW AAZKR ABCUV ABDBF ABJNI ABUWG ACAHQ ACBWZ ACCFJ ACGFS ACMXC ACPOU ACXQS ADBBV ADEOM ADIYS ADIZJ ADKYN ADMGS ADOZA ADPDF ADXAS ADZMN AEEZP AEIMD AENEX AEQDE AFBPY AFGKR AFKRA AFPWT AHMBA AIACR AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZFZN AZVAB BDRZF BENPR BFHJK BHBCM BMXJE BRXPI BSCLL CAG CCPQU COF DCZOG DRFUL DRMAN DRSTM EBD EBS EJD EMOBN ESX F5P FEDTE FUBAC FYUFA G-S GODZA GROUPED_DOAJ HMCUK HVGLF HZ~ KBYEO LATKE LEEKS LH4 LITHE LOXES LUTES LW6 LYRES MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM MY. MY~ NQS O66 O9- OIG OK1 OVD OVEED P2W P4E PQQKQ QB0 ROL RPM RX1 SUPJJ SV3 TEORI TUS UKHRP WBKPD WHWMO WIH WIJ WIK WOHZO WVDHM WYJ XG1 XV2 ZZTAW AANHP AAYCA ACCMX ACRPL ACUHS ACYXJ ADNMO CGR CUY CVF ECM EIF NPM AAMMB AEFGJ AGQPQ AGXDD AIDQK AIDYY K9. 7X8 WIN |
| ID | FETCH-LOGICAL-i3235-b2acc3a395a2f2b2ae67b50b57c542172fd64cd8ea73e785f2552ec9306552173 |
| ISSN | 1753-0393 1753-0407 |
| IngestDate | Fri Sep 05 12:01:15 EDT 2025 Fri Jul 25 08:00:45 EDT 2025 Wed Feb 19 01:51:02 EST 2025 Wed Jan 22 16:33:18 EST 2025 Wed Oct 30 09:56:37 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-i3235-b2acc3a395a2f2b2ae67b50b57c542172fd64cd8ea73e785f2552ec9306552173 |
| Notes | istex:4F0C4F0975F84D36F78B4B41818591D1E6E3CA51 ArticleID:JDB12025 Natural Science Foundation of Fujian Province - No. C071002; No. 2009Y0011; No. 2011J01127; No. 2011J06012 ark:/67375/WNG-VLZ4QGBN-9 Natural Science Foundation of China - No. 81170774; No. 81270874 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 23298195 |
| PQID | 1346137168 |
| PQPubID | 1006352 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_1347256719 proquest_journals_1346137168 pubmed_primary_23298195 wiley_primary_10_1111_1753_0407_12025_JDB12025 istex_primary_ark_67375_WNG_VLZ4QGBN_9 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-06 June 2013 2013-Jun 20130601 |
| PublicationDateYYYYMMDD | 2013-06-01 |
| PublicationDate_xml | – month: 06 year: 2013 text: 2013-06 |
| PublicationDecade | 2010 |
| PublicationPlace | Australia |
| PublicationPlace_xml | – name: Australia – name: Hoboken |
| PublicationTitle | Journal of diabetes |
| PublicationTitleAlternate | Journal of Diabetes |
| PublicationYear | 2013 |
| Publisher | Blackwell Publishing Ltd John Wiley & Sons, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: John Wiley & Sons, Inc |
| References | Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007; 447: 661-678. Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007; 316: 889-894. Tsai FJ, Yang CF, Chen CC et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010; 6: e1000847. Ordovas JM. Genetic links between diabetes mellitus and coronary atherosclerosis. Curr Atheroscler Rep. 2007; 9: 204-210. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16: 31-41. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28: 412-419. Levey AS, Coresh J, Balk E et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med. 2003; 139: 137-147. Minton JA, Hattersley AT, Owen K et al. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes. 2002; 51: 1287-1290. Chobanian AV, Bakris GL, Black HR et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42: 1206-1252. Hu C, Wang C, Zhang R et al. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia. 2009; 52: 1322-1325. Xu M, Bi Y, Xu Y et al. Combined effects of 19 common variations on type 2 diabetes in Chinese: Results from two community-based studies. PLoS One. 2010; 5: e14022. Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007; 316: 1336-1341. Wang C, Hu C, Zhang R et al. Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population. Diabetes. 2009; 58: 1023-1027. Bonetti S, Trombetta M, Boselli ML et al. Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: The Verona newly diagnosed type 2 diabetes study 2. Diabetes Care. 2011; 34: 1205-1210. Yang W, Lu J, Weng J et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362: 1090-1101. Chang YC, Chang TJ, Jiang YD et al. Association study of the genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007; 56: 2631-2637. Tam CH, Ho JS, Wang Y et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One. 2010; 5: e11428. Li H, Wu Y, Loos RJ et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008; 57: 264-268. Wu Y, Li H, Loos RJ et al. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008; 57: 2834-2842. Xiang J, Li XY, Xu M et al. Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab. 2008; 93: 4107-4112. The Pooling Project Research Group. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the pooling project. J Chronic Dis. 1978; 31: 201-306. Hardy C, Khanim F, Torres R et al. Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. Am J Hum Genet. 1999; 65: 1279-1290. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med. 1998; 15: 539-553. Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007; 3: e115. Franceschini N, Shara NM, Wang H et al. The association of genetic variants of type 2 diabetes with kidney function. Kidney Int. 2012; 82: 220-225. Han X, Luo Y, Ren Q et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet. 2010; 11: 81-89. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39: S1-266. Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916; 17: 863-871. Qi Q, Li H, Wu Y et al. Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population. Diabetologia. 2010; 53: 2163-2166. Lin Y, Li P, Cai L et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet. 2010; 11: 97-104. Rönn T, Wen J, Yang Z et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009; 52: 830-833. Grant RW, Moore AF, Florez JC. Genetic architecture of type 2 diabetes: Recent progress and clinical implications. Diabetes Care. 2009; 32: 1107-1114. Ng MC, Park KS, Oh B et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes. 2008; 57: 2226-2233. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316: 1331-1336. Wolever TM, Chiasson JL, Csima A et al. Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose. Diabetes Care. 1998; 21: 336-340. Zeggini E, Scott LJ, Saxena R et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008; 40: 638-645. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502. Perry JR, McCarthy MI, Hattersley AT et al. Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes. 2009; 58: 1463-1467. Blackburn H, Keys A, Simonson E, Rautaharju P, Punsar S. The electrocardiogram in population studies. A classification system. Circulation. 1960; 21: 1160-1175. 2012; 82 2002; 39 2010; 11 1985; 28 2010; 53 2003; 139 2007; 447 1978; 31 2002; 51 2010; 362 2008; 57 1999; 65 2011; 34 1998; 21 2007; 56 2008; 93 1998; 15 2009; 58 2009; 52 2007; 316 1960; 21 2009; 32 2007; 9 1916; 17 2007; 3 2008; 40 2010; 5 1976; 16 1972; 18 2003; 42 2010; 6 |
| References_xml | – reference: Hardy C, Khanim F, Torres R et al. Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1. Am J Hum Genet. 1999; 65: 1279-1290. – reference: Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502. – reference: Wolever TM, Chiasson JL, Csima A et al. Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose. Diabetes Care. 1998; 21: 336-340. – reference: Chang YC, Chang TJ, Jiang YD et al. Association study of the genetic polymorphisms of transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007; 56: 2631-2637. – reference: Li H, Wu Y, Loos RJ et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes. 2008; 57: 264-268. – reference: Bonetti S, Trombetta M, Boselli ML et al. Variants of GCKR affect both β-cell and kidney function in patients with newly diagnosed type 2 diabetes: The Verona newly diagnosed type 2 diabetes study 2. Diabetes Care. 2011; 34: 1205-1210. – reference: Wu Y, Li H, Loos RJ et al. Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes. 2008; 57: 2834-2842. – reference: Minton JA, Hattersley AT, Owen K et al. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations. Diabetes. 2002; 51: 1287-1290. – reference: Xiang J, Li XY, Xu M et al. Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese. J Clin Endocrinol Metab. 2008; 93: 4107-4112. – reference: Tsai FJ, Yang CF, Chen CC et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 2010; 6: e1000847. – reference: Rönn T, Wen J, Yang Z et al. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia. 2009; 52: 830-833. – reference: Yang W, Lu J, Weng J et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362: 1090-1101. – reference: Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetes Med. 1998; 15: 539-553. – reference: Tam CH, Ho JS, Wang Y et al. Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PLoS One. 2010; 5: e11428. – reference: Ordovas JM. Genetic links between diabetes mellitus and coronary atherosclerosis. Curr Atheroscler Rep. 2007; 9: 204-210. – reference: Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007; 316: 1336-1341. – reference: Lin Y, Li P, Cai L et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet. 2010; 11: 97-104. – reference: Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16: 31-41. – reference: Han X, Luo Y, Ren Q et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet. 2010; 11: 81-89. – reference: The Pooling Project Research Group. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the pooling project. J Chronic Dis. 1978; 31: 201-306. – reference: Scuteri A, Sanna S, Chen WM et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007; 3: e115. – reference: Perry JR, McCarthy MI, Hattersley AT et al. Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes. 2009; 58: 1463-1467. – reference: Franceschini N, Shara NM, Wang H et al. The association of genetic variants of type 2 diabetes with kidney function. Kidney Int. 2012; 82: 220-225. – reference: Wang C, Hu C, Zhang R et al. Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population. Diabetes. 2009; 58: 1023-1027. – reference: Grant RW, Moore AF, Florez JC. Genetic architecture of type 2 diabetes: Recent progress and clinical implications. Diabetes Care. 2009; 32: 1107-1114. – reference: Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316: 1331-1336. – reference: Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007; 316: 889-894. – reference: Qi Q, Li H, Wu Y et al. Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population. Diabetologia. 2010; 53: 2163-2166. – reference: Levey AS, Coresh J, Balk E et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med. 2003; 139: 137-147. – reference: Blackburn H, Keys A, Simonson E, Rautaharju P, Punsar S. The electrocardiogram in population studies. A classification system. Circulation. 1960; 21: 1160-1175. – reference: Xu M, Bi Y, Xu Y et al. Combined effects of 19 common variations on type 2 diabetes in Chinese: Results from two community-based studies. PLoS One. 2010; 5: e14022. – reference: Hu C, Wang C, Zhang R et al. Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population. Diabetologia. 2009; 52: 1322-1325. – reference: Zeggini E, Scott LJ, Saxena R et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008; 40: 638-645. – reference: Du Bois D, Du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med. 1916; 17: 863-871. – reference: Chobanian AV, Bakris GL, Black HR et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003; 42: 1206-1252. – reference: Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985; 28: 412-419. – reference: National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39: S1-266. – reference: Ng MC, Park KS, Oh B et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes. 2008; 57: 2226-2233. – reference: Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007; 447: 661-678. – volume: 11 start-page: 97 year: 2010 end-page: 104 article-title: Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population publication-title: BMC Med Genet – volume: 139 start-page: 137 year: 2003 end-page: 147 article-title: National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification publication-title: Ann Intern Med – volume: 53 start-page: 2163 year: 2010 end-page: 2166 article-title: Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population publication-title: Diabetologia – volume: 56 start-page: 2631 year: 2007 end-page: 2637 article-title: Association study of the genetic polymorphisms of transcription factor 7‐like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population publication-title: Diabetes – volume: 57 start-page: 264 year: 2008 end-page: 268 article-title: Variants in the fat mass‐ and obesity‐associated (FTO) gene are not associated with obesity in a Chinese Han population publication-title: Diabetes – volume: 21 start-page: 336 year: 1998 end-page: 340 article-title: Variation of postprandial plasma glucose, palatability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose publication-title: Diabetes Care – volume: 65 start-page: 1279 year: 1999 end-page: 1290 article-title: Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1 publication-title: Am J Hum Genet – volume: 32 start-page: 1107 year: 2009 end-page: 1114 article-title: Genetic architecture of type 2 diabetes: Recent progress and clinical implications publication-title: Diabetes Care – volume: 52 start-page: 1322 year: 2009 end-page: 1325 article-title: Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population publication-title: Diabetologia – volume: 82 start-page: 220 year: 2012 end-page: 225 article-title: The association of genetic variants of type 2 diabetes with kidney function publication-title: Kidney Int – volume: 39 start-page: S1 year: 2002 end-page: 266 article-title: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification publication-title: Am J Kidney Dis – volume: 3 start-page: e115 year: 2007 article-title: Genome‐wide association scan shows genetic variants in the FTO gene are associated with obesity‐related traits publication-title: PLoS Genet – volume: 17 start-page: 863 year: 1916 end-page: 871 article-title: A formula to estimate the approximate surface area if height and weight be known publication-title: Arch Intern Med – volume: 5 start-page: e14022 year: 2010 article-title: Combined effects of 19 common variations on type 2 diabetes in Chinese: Results from two community‐based studies publication-title: PLoS One – volume: 6 start-page: e1000847 year: 2010 article-title: A genome‐wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese publication-title: PLoS Genet – volume: 16 start-page: 31 year: 1976 end-page: 41 article-title: Prediction of creatinine clearance from serum creatinine publication-title: Nephron – volume: 362 start-page: 1090 year: 2010 end-page: 1101 article-title: Prevalence of diabetes among men and women in China publication-title: N Engl J Med – volume: 316 start-page: 1331 year: 2007 end-page: 1336 article-title: Genome‐wide association analysis identifies loci for type 2 diabetes and triglyceride levels publication-title: Science – volume: 15 start-page: 539 year: 1998 end-page: 553 article-title: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation publication-title: Diabetes Med – volume: 316 start-page: 1336 year: 2007 end-page: 1341 article-title: Replication of genome‐wide association signals in UK samples reveals risk loci for type 2 diabetes publication-title: Science – volume: 11 start-page: 81 year: 2010 end-page: 89 article-title: Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population publication-title: BMC Med Genet – volume: 21 start-page: 1160 year: 1960 end-page: 1175 article-title: The electrocardiogram in population studies. A classification system publication-title: Circulation – volume: 40 start-page: 638 year: 2008 end-page: 645 article-title: Meta‐analysis of genome‐wide association data and large‐scale replication identifies additional susceptibility loci for type 2 diabetes publication-title: Nat Genet – volume: 31 start-page: 201 year: 1978 end-page: 306 article-title: Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: Final report of the pooling project publication-title: J Chronic Dis – volume: 58 start-page: 1463 year: 2009 end-page: 1467 article-title: Interrogating type 2 diabetes genome‐wide association data using a biological pathway‐based approach publication-title: Diabetes – volume: 57 start-page: 2226 year: 2008 end-page: 2233 article-title: Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians publication-title: Diabetes – volume: 58 start-page: 1023 year: 2009 end-page: 1027 article-title: Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population publication-title: Diabetes – volume: 42 start-page: 1206 year: 2003 end-page: 1252 article-title: Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure publication-title: Hypertension – volume: 52 start-page: 830 year: 2009 end-page: 833 article-title: A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals publication-title: Diabetologia – volume: 28 start-page: 412 year: 1985 end-page: 419 article-title: Homeostasis model assessment: Insulin resistance and beta‐cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia – volume: 9 start-page: 204 year: 2007 end-page: 210 article-title: Genetic links between diabetes mellitus and coronary atherosclerosis publication-title: Curr Atheroscler Rep – volume: 57 start-page: 2834 year: 2008 end-page: 2842 article-title: Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population publication-title: Diabetes – volume: 447 start-page: 661 year: 2007 end-page: 678 article-title: Genome‐wide association study of 14,000 cases of seven common diseases and 3,000 shared controls publication-title: Nature – volume: 5 start-page: e11428 year: 2010 article-title: Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta‐cell function in Chinese subjects publication-title: PLoS One – volume: 93 start-page: 4107 year: 2008 end-page: 4112 article-title: Zinc transporter‐8 gene (SLC30A8) is associated with type 2 diabetes in Chinese publication-title: J Clin Endocrinol Metab – volume: 316 start-page: 889 year: 2007 end-page: 894 article-title: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity publication-title: Science – volume: 51 start-page: 1287 year: 2002 end-page: 1290 article-title: Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations publication-title: Diabetes – volume: 34 start-page: 1205 year: 2011 end-page: 1210 article-title: Variants of GCKR affect both β‐cell and kidney function in patients with newly diagnosed type 2 diabetes: The Verona newly diagnosed type 2 diabetes study 2 publication-title: Diabetes Care – volume: 18 start-page: 499 year: 1972 end-page: 502 article-title: Estimation of the concentration of low‐density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge publication-title: Clin Chem |
| SSID | ssj0067663 |
| Score | 2.173884 |
| Snippet | Background
Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17... Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related... Background Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17... |
| SourceID | proquest pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 136 |
| SubjectTerms | Alleles Asian Continental Ancestry Group Cardiovascular Diseases - ethnology Cardiovascular Diseases - genetics Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetic Nephropathies - ethnology Diabetic Nephropathies - genetics estimated glomerular filtration rate Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Genetic Variation Genotype Humans Minnesota Code Polymorphism, Single Nucleotide Risk Factors single nucleotide polymorphism Type 2 diabetes mellitus 估算肾小球滤过率，明尼苏达编码，单核苷酸多态性，2型糖尿病 |
| Title | Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population (中国畲族人群17个糖尿病相关基因位点的遗传变异与心血管风险和糖尿病肾病的相关性) |
| URI | https://api.istex.fr/ark:/67375/WNG-VLZ4QGBN-9/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2F1753-0407.12025 https://www.ncbi.nlm.nih.gov/pubmed/23298195 https://www.proquest.com/docview/1346137168 https://www.proquest.com/docview/1347256719 |
| Volume | 5 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bj9JAFJ6Q3cT4YryLrmZMXKPZFGk706GPsFw2GxZjBMV9adphGolJ2Sxg1N-zxsT_oCbwn3z2nJm2lF006ksznA5T4Hycy8y5EPJIymosQyYt349H4KAw26qFEbciV0Uekyp0HMwdPup5BwN2OOTDUulnIWppPosq8tPGvJL_4SrQgK-YJfsPnM0XBQKMgb9wBQ7D9a94XPhtTZ1YNP1gNiYm7r0HLzgLcrFFvslq6ewVMDNxHjCxDdpsbLLb1kNTddA50s07YcVEnWBTBbAZP2bhkdh-W03V3ktMuMp7gaHZqk_gxe6-s9to4bXObKFpTNOaesz1uB1n-xEXreTsY6_CEIyc7ISpygXacK4VybwQXmQqI7wBvfx2niuermm9PRyH4M8nxf0O3XuiuN-xIaDoQtQoVh-1MOnYKLkCjZkWu5no5wWEOwUxbpuiLL9RL_lSFdupmrTt9ULevedBe9DtBv3WsL9-VxsOeLQKgtXFegvbjhAYXrBdbzQb7cyG8ISnewDmXyQtSoUxaOeeDk4VyoMPmzykdYdLW0z9q-RKykRaN7i9RkoquU4uHaXBHDfI1wJ8qYYvncQ0hS_N4Is0W9Dz8NXzps8QvBRAStfBSxG8mp6BlxbAS8cJBfDSFLwUwEtX4KVPll8W3xdntlieLb4tPy9-xE9vkkG71d8_sNLWIdbYdVwQNU4opRu6Pg-d2IFXyhMRr0ZcSM6wJ1s8Akk0qqlQuErUeAyetaOkDw40DGzh3iJbySRRdwiVknPFQhZFvs-kPfJHDixb9ST3WORW_TJ5rBkQnJjyMEF4-g6jJQUPXvc6wavuMXvRafQCmLiTcShIhcg0sF0GBjVAoFYmD_PbIOLx3C5M1GSu5wjwTIQNS9w2nM0fBg6Rj0fhZVLRrM5vZM49wiVAuAQaLsFhs6EHd__8ae6Ry6s_3w7Zmp3O1X0wv2fRgxSrvwACftkf |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+study+of+genetic+variants+of+17+diabetes-related+genes%2Floci+and+cardiovascular+risk+and+diabetic+nephropathy+in+the+Chinese+She+population+%28%C3%A7%C2%BE%C2%A417%C3%A4%C2%BD%C3%A5%C2%BFf%29&rft.jtitle=Journal+of+diabetes&rft.au=Chen%2C+Gang&rft.au=Xu%2C+Yuan&rft.au=Lin%2C+Yinghua&rft.au=Lai%2C+Xiaolan&rft.date=2013-06-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1753-0393&rft.eissn=1753-0407&rft.volume=5&rft.issue=2&rft.spage=136&rft_id=info:doi/10.1111%2F1753-0407.12025&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=2954730341 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1753-0393&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1753-0393&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1753-0393&client=summon |