The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction

• Published in: Journal of pineal research Vol. 54; no. 4; pp. 442 - 452
• Main Authors: Espino, Javier, Rodríguez, Ana B., Pariente, José A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2013
• Subjects: Adolescent; Adult; Apoptosis - drug effects; Blotting, Western; cell death; Cells, Cultured; Humans; leucocytes; Leukocytes - cytology; Leukocytes - drug effects; Leukocytes - metabolism; melatonin; Melatonin - pharmacology; Middle Aged; MT receptor; Protein Binding; protein kinases; Reactive Oxygen Species; Receptor, Melatonin, MT1 - metabolism; Receptor, Melatonin, MT2 - metabolism; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - pharmacology; tumour necrosis factor-α; Young Adult; protein kinases; MT receptor; cell death; melatonin; tumour necrosis factor‐α; leucocytes

The pro‐apoptotic signalling cascades induced by tumour necrosis factor‐alpha (TNF‐α) have been intensively studied in multiple cellular systems. So far, it is known that TNF‐α can simultaneously activate survival and apoptotic cell death responses. The balance between these signals determines the u...