Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects

• Published in: Journal of clinical pharmacology Vol. 46; no. 5; p. 549
• Main Authors: Kubitza, Dagmar, Becka, Michael, Zuehlsdorf, Michael, Mueck, Wolfgang
• Format: Journal Article
• Language: English
• Published: England 01.05.2006
• Subjects: Adult; Aluminum Hydroxide - pharmacology; Antacids - pharmacology; Cross-Over Studies; Dietary Carbohydrates - pharmacology; Dietary Fats - pharmacology; Drug Combinations; Drug Interactions; Factor Xa Inhibitors; Fasting - metabolism; Food-Drug Interactions; Histamine H2 Antagonists - pharmacology; Humans; Intestinal Absorption - drug effects; Magnesium Hydroxide - pharmacology; Male; Morpholines - adverse effects; Morpholines - blood; Morpholines - pharmacokinetics; Morpholines - pharmacology; Prothrombin Time; Ranitidine - pharmacology; Rivaroxaban; Thiophenes - adverse effects; Thiophenes - blood; Thiophenes - pharmacokinetics; Thiophenes - pharmacology

To investigate the influence of food and administration of an antacid (aluminum-magnesium hydroxide) or ranitidine on the absorption of BAY 59-7939 (rivaroxaban), 4 randomized studies were performed in healthy male subjects. In 2 food interaction studies, subjects received BAY 59-7939, either as two...