5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease
Objective To investigate the association between 5‐HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). Methods This case‐control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clini...
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| Published in | International journal of geriatric psychiatry Vol. 19; no. 6; pp. 523 - 526 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.06.2004
Wiley Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0885-6230 1099-1166 |
| DOI | 10.1002/gps.1109 |
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| Abstract | Objective
To investigate the association between 5‐HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD).
Methods
This case‐control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty‐seven subjects with NINCDS‐ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5‐HT2A receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI).
Results
The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05).
Conclusions
Specific NP symptoms in AD were significantly associated with 5‐HT2A receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5‐HT2A receptor polymorphisms are worthy of further exploration. Copyright © 2004 John Wiley & Sons, Ltd. |
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| AbstractList | Objective To investigate the association between 5-HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). Methods This case-control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty-seven subjects with NINCDS-ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5-HT2A receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI). Results The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05). Conclusions Specific NP symptoms in AD were significantly associated with 5-HT2A receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5-HT2A receptor polymorphisms are worthy of further exploration. To investigate the association between 5-HT(2A) receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). This case-control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty-seven subjects with NINCDS-ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5-HT(2A) receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI). The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05). Specific NP symptoms in AD were significantly associated with 5-HT(2A) receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5-HT(2A) receptor polymorphisms are worthy of further exploration. Objective To investigate the association between 5‐HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). Methods This case‐control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty‐seven subjects with NINCDS‐ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5‐HT2A receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI). Results The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05). Conclusions Specific NP symptoms in AD were significantly associated with 5‐HT2A receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5‐HT2A receptor polymorphisms are worthy of further exploration. Copyright © 2004 John Wiley & Sons, Ltd. OBJECTIVETo investigate the association between 5-HT(2A) receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD).METHODSThis case-control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty-seven subjects with NINCDS-ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5-HT(2A) receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI).RESULTSThe genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05).CONCLUSIONSSpecific NP symptoms in AD were significantly associated with 5-HT(2A) receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5-HT(2A) receptor polymorphisms are worthy of further exploration. Objective To investigate the association between 5-HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). Methods This case-control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty-seven subjects with NINCDS-ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5-HT2A receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI). Results The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05). Conclusions Specific NP symptoms in AD were significantly associated with 5-HT2A receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5-HT2A receptor polymorphisms are worthy of further exploration. [PUBLICATION ABSTRACT] |
| Author | Tang, Nelson Leung Sang Ma, Suk Ling Chiu, Helen Fung Kum Lam, Linda Chiu Wa Zhang, Weimin |
| Author_xml | – sequence: 1 givenname: Linda Chiu Wa surname: Lam fullname: Lam, Linda Chiu Wa email: cwlam@cuhk.edu.hk organization: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC – sequence: 2 givenname: Nelson Leung Sang surname: Tang fullname: Tang, Nelson Leung Sang organization: Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC – sequence: 3 givenname: Suk Ling surname: Ma fullname: Ma, Suk Ling organization: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC – sequence: 4 givenname: Weimin surname: Zhang fullname: Zhang, Weimin organization: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC – sequence: 5 givenname: Helen Fung Kum surname: Chiu fullname: Chiu, Helen Fung Kum organization: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC |
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| Keywords | Human 5-HT2A serotonin receptor Symptomatology Nervous system diseases Genetic variability Alzheimer disease Central nervous system disease Degenerative disease Elderly Cerebral disorder Geriatrics Polymorphism |
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| References | Bjork JM, Moeller FG, Dougherty DM, et al. 2002. Serotonin 2a receptor T102C polymorphism and impaired impulse control. Am J Med Genet 114: 336-339. Forstl H, Burns A, Levy R, Cairns N. 1994. Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease. Br J Psychiatry 165: 53-59. Namias B, Tedde A, Forleo P, et al. 2001. Association between 5-HT(2A) receptor polymorphims and psychotic symptoms in Alzheimer's disease. Biological Psychiatry 50(6): 472-475. Leung VPY, Lam LCW, Chiu HFK, Cummings J, Chen QL. 2001. Validation study of the Chinese version of the neuropsychiatric inventory (CNPI). Int J Geriatr Psychiatry 16: 789-793. Gursoy S, Erdal E, Herken H, Madeni E, Alasehirli B. 2001. Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fribromyalgia syndrome. Rheumatol Int 21: 58-61. Chiu HFK, Lee HC, Chung WS, Kwong PK. 1994. Reliability and validity of the Cantonese version of the Mini-Mental State Examination-a preliminary study. J Hong Kong Coll Psychiatrists 4(Suppl. 2): 25-28. Lane HY, Chan YC, Chiu CC, et al. 2002. Association of risperidone treatment response with a polymorphism in the 5HT(2A) receptor gene. Am J Psychiatry 159: 1593-1595. Holmes C, Arranz MJ, Powell JF, Collier DA, Lovestone S. 1998. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Hum Mol Genet 7(9): 1507-1509. Liu HC, Hong CJ, Liu CY, et al. 2001. Association analysis of the 5-HT receptor polymorphisms C267T with depression in patients with Alzheimer's disease. Psychiatry Clin Neurosci 55(4): 427-429. Tsukamoto K, Watanabe T, Matsushima T, et al. 1993. Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 121: 598-602. de Angelis L. 2002. 5-HT2A antagonists in psychiatric disorders. Curr Opin Investig Drugs 3: 106-112. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM, et al. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force in Alzheimer's disease. Neurology 34: 939-944. Arias B, Gutierrez B, Pintor L, Gasto C, Fananas L. 2001. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression. Mol Psychiatry 6: 239-242. Chan AS, Choi A, Chiu H, Lam L. 2003. Clinical validity of the Chinese version of Mattis Dementia Rating Scale in differentiating dementia of Alzheimer's type in Hong Kong. J Int Neuropsychol Soc 9: 45-55. Correa H, De Marco L, Boson W, et al. 2002. Analysis of T102C 5HT2A polymorphism in Brazilian psychiatric inpatients: relationship with suicidal behavior. Cell Mol Neurobiol 22: 813-817. Mintzer JE. 2001. Underlying mechanism of psychosis and aggression in patients with Alzheimer's disease. J Clin Psychiatry 62(Suppl. 21): 23-25. 1994; 165 2001; 50 2001; 6 2002; 114 1984; 34 2003; 9 2002; 22 2002; 3 2002; 159 2001; 16 1998; 7 2001; 55 2001; 62 1993; 121 1994; 4 2001; 21 |
| References_xml | – reference: Liu HC, Hong CJ, Liu CY, et al. 2001. Association analysis of the 5-HT receptor polymorphisms C267T with depression in patients with Alzheimer's disease. Psychiatry Clin Neurosci 55(4): 427-429. – reference: Namias B, Tedde A, Forleo P, et al. 2001. Association between 5-HT(2A) receptor polymorphims and psychotic symptoms in Alzheimer's disease. Biological Psychiatry 50(6): 472-475. – reference: de Angelis L. 2002. 5-HT2A antagonists in psychiatric disorders. Curr Opin Investig Drugs 3: 106-112. – reference: Holmes C, Arranz MJ, Powell JF, Collier DA, Lovestone S. 1998. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Hum Mol Genet 7(9): 1507-1509. – reference: Lane HY, Chan YC, Chiu CC, et al. 2002. Association of risperidone treatment response with a polymorphism in the 5HT(2A) receptor gene. Am J Psychiatry 159: 1593-1595. – reference: Mintzer JE. 2001. Underlying mechanism of psychosis and aggression in patients with Alzheimer's disease. J Clin Psychiatry 62(Suppl. 21): 23-25. – reference: Bjork JM, Moeller FG, Dougherty DM, et al. 2002. Serotonin 2a receptor T102C polymorphism and impaired impulse control. Am J Med Genet 114: 336-339. – reference: Chan AS, Choi A, Chiu H, Lam L. 2003. Clinical validity of the Chinese version of Mattis Dementia Rating Scale in differentiating dementia of Alzheimer's type in Hong Kong. J Int Neuropsychol Soc 9: 45-55. – reference: Tsukamoto K, Watanabe T, Matsushima T, et al. 1993. Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med 121: 598-602. – reference: Gursoy S, Erdal E, Herken H, Madeni E, Alasehirli B. 2001. Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fribromyalgia syndrome. Rheumatol Int 21: 58-61. – reference: Leung VPY, Lam LCW, Chiu HFK, Cummings J, Chen QL. 2001. Validation study of the Chinese version of the neuropsychiatric inventory (CNPI). Int J Geriatr Psychiatry 16: 789-793. – reference: Chiu HFK, Lee HC, Chung WS, Kwong PK. 1994. Reliability and validity of the Cantonese version of the Mini-Mental State Examination-a preliminary study. J Hong Kong Coll Psychiatrists 4(Suppl. 2): 25-28. – reference: Arias B, Gutierrez B, Pintor L, Gasto C, Fananas L. 2001. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression. Mol Psychiatry 6: 239-242. – reference: McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM, et al. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force in Alzheimer's disease. Neurology 34: 939-944. – reference: Forstl H, Burns A, Levy R, Cairns N. 1994. Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease. Br J Psychiatry 165: 53-59. – reference: Correa H, De Marco L, Boson W, et al. 2002. Analysis of T102C 5HT2A polymorphism in Brazilian psychiatric inpatients: relationship with suicidal behavior. Cell Mol Neurobiol 22: 813-817. – volume: 165 start-page: 53 year: 1994 end-page: 59 article-title: Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease publication-title: Br J Psychiatry – volume: 16 start-page: 789 year: 2001 end-page: 793 article-title: Validation study of the Chinese version of the neuropsychiatric inventory (CNPI) publication-title: Int J Geriatr Psychiatry – volume: 34 start-page: 939 year: 1984 end-page: 944 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS‐ADRDA work group under the auspices of Department of Health and Human Services task force in Alzheimer's disease publication-title: Neurology – volume: 62 start-page: 23 issue: Suppl. 21 year: 2001 end-page: 25 article-title: Underlying mechanism of psychosis and aggression in patients with Alzheimer's disease publication-title: J Clin Psychiatry – volume: 3 start-page: 106 year: 2002 end-page: 112 article-title: 5‐HT antagonists in psychiatric disorders publication-title: Curr Opin Investig Drugs – volume: 21 start-page: 58 year: 2001 end-page: 61 article-title: Association of T102C polymorphism of the 5‐HT2A receptor gene with psychiatric status in fribromyalgia syndrome publication-title: Rheumatol Int – volume: 159 start-page: 1593 year: 2002 end-page: 1595 article-title: Association of risperidone treatment response with a polymorphism in the 5HT(2A) receptor gene publication-title: Am J Psychiatry – volume: 55 start-page: 427 issue: 4 year: 2001 end-page: 429 article-title: Association analysis of the 5‐HT receptor polymorphisms C267T with depression in patients with Alzheimer's disease publication-title: Psychiatry Clin Neurosci – volume: 114 start-page: 336 year: 2002 end-page: 339 article-title: Serotonin 2a receptor T102C polymorphism and impaired impulse control publication-title: Am J Med Genet – volume: 4 start-page: 25 issue: Suppl. 2 year: 1994 end-page: 28 article-title: Reliability and validity of the Cantonese version of the Mini‐Mental State Examination—a preliminary study publication-title: J Hong Kong Coll Psychiatrists – volume: 7 start-page: 1507 issue: 9 year: 1998 end-page: 1509 article-title: 5‐HT and 5‐HT receptor polymorphisms and psychopathology in late onset Alzheimer's disease publication-title: Hum Mol Genet – volume: 50 start-page: 472 issue: 6 year: 2001 end-page: 475 article-title: Association between 5‐HT(2A) receptor polymorphims and psychotic symptoms in Alzheimer's disease publication-title: Biological Psychiatry – volume: 121 start-page: 598 year: 1993 end-page: 602 article-title: Determination by PCR‐RFLP of apo E genotype in a Japanese population publication-title: J Lab Clin Med – volume: 9 start-page: 45 year: 2003 end-page: 55 article-title: Clinical validity of the Chinese version of Mattis Dementia Rating Scale in differentiating dementia of Alzheimer's type in Hong Kong publication-title: J Int Neuropsychol Soc – volume: 22 start-page: 813 year: 2002 end-page: 817 article-title: Analysis of T102C 5HT2A polymorphism in Brazilian psychiatric inpatients: relationship with suicidal behavior publication-title: Cell Mol Neurobiol – volume: 6 start-page: 239 year: 2001 end-page: 242 article-title: Variability in the 5‐HT(2A) receptor gene is associated with seasonal pattern in major depression publication-title: Mol Psychiatry |
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To investigate the association between 5‐HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease... To investigate the association between 5-HT(2A) receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). This... Objective To investigate the association between 5-HT2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease... OBJECTIVETo investigate the association between 5-HT(2A) receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease... |
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| SubjectTerms | 5-HT2A receptor polymorphism Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Delusions - genetics Genetic Predisposition to Disease Genotype Geriatric psychiatry Geriatrics Humans Medical sciences Middle Aged Neurology Neuropsychological Tests Polymorphism Polymorphism, Genetic psychiatric symptoms Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptor, Serotonin, 5-HT2A - genetics Social Behavior Disorders - genetics |
| Title | 5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease |
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