Phosphorylation of STAT3 correlates with HER2 status, but not with survival in pancreatic ductal adenocarcinoma

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 122; no. 6; pp. 476 - 481
• Main Authors: Koperek, Oskar, Aumayr, Klaus, Schindl, Martin, Werba, Gregor, Soleiman, Afschin, Schoppmann, Sebastian, Sahora, Klaus, Birner, Peter
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.06.2014; Wiley Subscription Services, Inc
• Subjects: Aged; Aggressive behavior; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Female; Gene Amplification; Genes, erbB-2; HER2; Humans; Immunohistochemistry; In Situ Hybridization; Male; Middle Aged; pancreatic ductal adenocarcinoma; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Phosphorylation; Prognosis; pSTAT3; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Retrospective Studies; STAT3 Transcription Factor - chemistry; STAT3 Transcription Factor - metabolism; pSTAT3; HER2; pancreatic ductal adenocarcinoma

Activation of signal‐transcriptional factor signal transducer and activator of transcription 3 (STAT3) is associated with more aggressive behaviour in a variety of human malignancies. As selective STAT3 inhibitors exist, this protein might represent a novel therapeutic target. Although STAT3 seems t...