COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

• Published in: Depression and anxiety Vol. 30; no. 6; pp. 515 - 527
• Main Authors: McIntyre, Roger S., Cha, Danielle S., Soczynska, Joanna K., Woldeyohannes, Hanna O., Gallaugher, Laura Ashley, Kudlow, Paul, Alsuwaidan, Mohammad, Baskaran, Anusha
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2013; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; Aged; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - physiopathology; cognitive deficits; cognitive dysfunction; dementia; Depressive Disorder, Major - complications; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - physiopathology; duloxetine; functional outcome; Humans; major depressive disorder; Middle Aged; Neurology; vortioxetine; Young Adult

Background Few reports have aimed to describe the mediational effect of cognitive deficits on functional outcomes in major depressive disorder (MDD), and relatively few interventions are demonstrated to mitigate cognitive deficits in MDD. Methods Studies enrolling subjects between the ages of 18–65...