MicroRNA-214 Protects Cardiac Myocytes Against H2O2-Induced Injury

• Published in: Journal of cellular biochemistry Vol. 115; no. 1; pp. 93 - 101
• Main Authors: Lv, Guangwei, Shao, Suxia, Dong, Hua, Bian, Xiaohua, Yang, Xingwei, Dong, Shimin
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2014; Wiley Subscription Services, Inc
• Subjects: Animals; APOPTOSIS; Apoptosis - drug effects; Apoptosis - genetics; CARDIAC MYOCYTES; Cell Survival - drug effects; Cells, Cultured; Gene Expression Regulation - drug effects; H2O2; Hydrogen Peroxide - pharmacology; MicroRNA-214; MicroRNAs - physiology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; PHOSPHATASE AND TENSIN HOMOLOG (PTEN); PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Rats; Rats, Sprague-Dawley; APOPTOSIS; MicroRNA-214; PHOSPHATASE AND TENSIN HOMOLOG (PTEN); H2O2; CARDIAC MYOCYTES

ABSTRACT Reactive oxygen species (ROS)‐induced cardiac myocyte injury resulting from changes in the expression levels of multiple genes plays a critical role in the pathogenesis of numerous heart diseases. The purpose of this study was to determine the potential roles of microRNA‐214 (miR‐214) in hy...