Lung Permeability, Antioxidant Status, and NO2 Inhalation: A Selenium Supplementation Study in Rats

• Published in: Journal of Toxicology and Environmental Health, Part A: Strategies for Clean Air and Health Vol. 70; no. 3-4; pp. 284 - 294
• Main Authors: de Burbure, C. Y., Heilier, J.-F., Nève, J., Becker, A., Albrecht, C., Borm, P. J. A., Gromadzinska, J., Wasowicz, W., Rydzynski, K., Bernard, A. M.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.02.2007
• Subjects: Acid Phosphatase - metabolism; Air Pollutants - adverse effects; Alkaline Phosphatase - metabolism; Animals; Antioxidants - metabolism; Biomarkers - analysis; Biomarkers - blood; Bronchoalveolar Lavage Fluid - chemistry; Dietary Supplements; Dose-Response Relationship, Drug; Inhalation Exposure; L-Lactate Dehydrogenase - metabolism; Lung - drug effects; Male; Nitrogen Dioxide - adverse effects; Permeability - drug effects; Rats; Rats, Wistar; Selenium - pharmacology; Thiobarbituric Acid Reactive Substances - metabolism; Uteroglobin - metabolism

Little is known about antioxidant status, selenium status in particular, and lung response to NO 2 , which acts as a proinflammatory air pollutant. The effects of a low selenium diet (1.3 μg Se/d) with or without selenium supplementation were therefore studied in 128 Wistar rats, 2 mo old, male expo...