Inhibitory effect of Capsicum chinense and Piper nigrum fruits, capsaicin and piperine on aflatoxins production in Aspergillus parasiticus by downregulating the expression of aflD, aflM, aflR, and aflS genes of aflatoxins biosynthetic pathway

• Published in: Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes Vol. 55; no. 9; pp. 835 - 843
• Main Authors: Buitimea-Cantúa, Génesis V., Buitimea-Cantúa, Nydia E., Rocha-Pizaña, María del Refugio, Hernández-Morales, Alejandro, Magaña-Barajas, Elisa, Molina-Torres, Jorge
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 01.09.2020; Taylor & Francis Ltd
• Subjects: Aflatoxins; Aflatoxins biosynthesis; Aspergillus parasiticus; biochemical pathways; Biosynthesis; Capsaicin; Capsicum chinense; carcinogenicity; Carcinogens; dose response; environmental science; Fruits; Fungicides; Gene expression; Genes; growth retardation; Metabolites; multigene family; Mycotoxins; Piper nigrum; Piperine; quantitative polymerase chain reaction

Aflatoxins produced by Aspergillus parasiticus are toxic and carcinogenic metabolites. The biosynthesis of this mycotoxins is a complex process and involves at least 30 genes clustered within an approximately 82 kB gene cluster. In the present study, the effect of Capsicum chinense and Piper nigrum...