In vivo oriented modeling with consideration of intracellular crowding

• Published in: 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Vol. 2013; pp. 2716 - 2719
• Main Authors: Hiroi, Noriko, Iba, Keisuke, Tabira, Akito, Okuhara, Takahiro, Kubojima, Takeshi, Hiraiwa, Takumi, Kobayashi, Tetsuya J., Oka, Kotaro, Funahashi, Akira
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.01.2013
• Subjects: Biochemistry; Biological system modeling; Enzymes - metabolism; In vivo; Intracellular Space - metabolism; Kinetics; Lattices; Macromolecular Substances - metabolism; Models, Biological; Monte Carlo Method; Monte Carlo methods; Physiology; Substrate Specificity; Substrates; Time Factors

In vivo reaction space is constrained by complex structures which are made of entwined cytoskeletons and organelles; this create the difference between in vivo and in vitro in respect of molecular mobility, and it may affect reaction processes. Our motivation is to reveal the background mechanisms o...