Improved Longevity and Functionality of a Canine Model Providing Portal Vein and Multi-Site Intestinal Access

• Published in: Comparative medicine Vol. 50; no. 2; pp. 167 - 174
• Main Authors: Sutyak, John P., Lee, Yong-Hee, Perry, Barbara A., Stern, William, Makhey, Vijaya, Sinko, Patrick J.
• Format: Journal Article
• Language: English
• Published: United States American Association for Laboratory Animal Science 01.04.2000
• Subjects: administration & dosage; adverse effects; animal models; Animals; catheters; Catheters, Indwelling; Catheters, Indwelling - adverse effects; colon; Colon - diagnostic imaging; Colon - physiology; Dimethylpolysiloxanes; Dogs; drug delivery systems; duodenum; Duodenum - diagnostic imaging; Duodenum - physiology; Filtration; Filtration - instrumentation; ileum; Ileum - diagnostic imaging; Ileum - physiology; instrumentation; intestinal absorption; Intestinal Absorption - physiology; laboratory animals; Male; Models, Biological; Pharmaceutical Preparations; Pharmaceutical Preparations - administration & dosage; physiology; portal vein; Portal Vein - diagnostic imaging; Portal Vein - physiology; prevention & control; Radiography; research equipment; Sepsis; Sepsis - prevention & control; Silicones; Vascular Surgical Procedures

Background and Purpose: The canine intestinal and venous access port (IVAP) model is valuable for investigating hepatic elimination and region-specific intestinal absorption of pharmaceuticals. Previously, long-term functionality of this preparation has been variable. Methods: Catheters of different...