Efficacy of Dynamics-Based Features for Machine Learning Classification of Renal Hemodynamics

Different machine learning approaches for analyzing renal hemodynamics using time series of arterial blood pressure and renal blood flow rate measurements in conscious rats are developed and compared. Particular emphasis is placed on features used for machine learning. The test scenario involves bin...

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Published in2023 31st European Signal Processing Conference (EUSIPCO) Vol. 2023; pp. 1145 - 1149
Main Authors Chopde, Purva R., Alvarez-Cedron, Rocio, Alphonse, Sebastian, Polichnowski, Aaron J., Griffin, Karen A., Williamson, Geoffrey A.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States EURASIP 01.09.2023
Subjects
Artificial neural networks
biomedical signal processing
Hemodynamics
machine learning
nephrology
Particle measurements
physiology
Signal processing
Support vector machines
Time measurement
Time series analysis
nephrology
biomedical signal processing
physiology
machine learning
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Summary:Different machine learning approaches for analyzing renal hemodynamics using time series of arterial blood pressure and renal blood flow rate measurements in conscious rats are developed and compared. Particular emphasis is placed on features used for machine learning. The test scenario involves binary classification of Sprague-Dawley rats obtained from two different suppliers, with the suppliers' rat colonies having drifted slightly apart in hemodynamic characteristics. Models used for the classification include deep neural network (DNN), random forest, support vector machine, multilayer perceptron. While the DNN uses raw pressure/flow measurements as features, the latter three use a feature vector of parameters of a nonlinear dynamic system fitted to the pressure/flow data, thereby restricting the classification basis to the hemodynamics. Although the performance in these cases is slightly reduced in comparison to that of the DNN, they still show promise for machine learning (ML) application. The pioneering contribution of this work is the establishment that even with features limited to hemodynamics-based information, the ML models can successfully achieve classification with reasonably high accuracy.
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ISSN:2219-5491
2076-1465
2219-5491
DOI:10.23919/EUSIPCO58844.2023.10289999