Components of the transforming growth factor-β family and the pathogenesis of human Achilles tendon pathology—a genetic association study

• Published in: Rheumatology (Oxford, England) Vol. 49; no. 11; pp. 2090 - 2097
• Main Authors: Posthumus, Michael, Collins, Malcolm, Cook, Jill, Handley, Christopher J., Ribbans, William J., Smith, Roger K. W., Schwellnus, Martin P., Raleigh, Stuart M.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2010
• Subjects: Achilles Tendon - injuries; Adult; Alleles; Biological and medical sciences; Bone morphogenic protein 14; Cartilage-derived morphogenic protein 1; Case-Control Studies; Cohort Studies; Diseases of the osteoarticular system; Female; Gene; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Growth Differentiation Factor 5 - genetics; Growth/differentiation factor-5; Humans; Juxtaarticular diseases. Extraarticular rhumatism; Male; Medical sciences; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; Risk Factors; South Africa; Tendinopathy; Tendinopathy - genetics; Tendinopathy - physiopathology; Tendon injury; Tendon rupture; Transforming Growth Factor beta - genetics; Victoria; South Africa; Victoria; Juxtaarticular disease; Human; Family study; Transforming growth factor β; Pathogenesis; Tendo calcaneus; Cartilage-derived morphogenic protein 1; Diseases of the osteoarticular system; Rheumatology; Tendinopathy; Bone morphogenic protein 14; Protein; Growth/differentiation factor-5; Cartilage; Tendon rupture; Anatomic pathology; Tendinitis; Gene; Genetics; Tendon injury; Bone; Growth factor

Objectives. Achilles tendon pathology is a multifactorial condition for which various risk factors, including genetic factors, have been identified. Gene transfection of two members of the TGF-β family, TGF-β1 and growth/differentiation factor-5 (GDF-5), have been shown to enhance tendon repair and...