Relative contribution of dietary protein level and aflatoxin B1 dose in generation of presumptive preneoplastic foci in rat liver

• Published in: JNCI : Journal of the National Cancer Institute Vol. 78; no. 2; p. 365
• Main Authors: Dunaif, G E, Campbell, T C
• Format: Journal Article
• Language: English
• Published: United States 01.02.1987
• Subjects: Aflatoxin B1; Aflatoxins - administration & dosage; Animals; Caseins; Dietary Proteins; Dose-Response Relationship, Drug; Liver Neoplasms - etiology; Male; Precancerous Conditions - etiology; Rats; Rats, Inbred F344

Male weanling F344 rats were orally gavaged with aflatoxin B1 (AFB1) in daily doses of 200, 235, 270, 300, and 350 micrograms/kg/day for a total of 10 doses over a 12-day period, and then 1 week after the last dose they were fed diets of varying protein (casein) content to compare the contribution o...