1H-NMR spectroscopic study of the effect of aging vascular prostheses made of poly(ethylene terephthalate) on the macromolecular weight

• Published in: Journal of biomedical materials research. Part A Vol. 91A; no. 3; pp. 939 - 952
• Main Authors: Chaouch, W., Dieval, F., Le Nouen, D., Defoin, A., Chakfe, N., Durand, B.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2009
• Subjects: 1H-NMR spectroscopy; Blood Vessel Prosthesis; chemical aging; Derivatives; Humans; Hydrolysis; Macromolecular Substances; macromolecular weight; Magnetic Resonance Spectroscopy - methods; Materials Testing; Models, Chemical; Molecular Weight; polyethylene terephthalate; Polyethylene terephthalates; Polyethylene Terephthalates - chemistry; Prostheses; Prosthesis Failure; Prosthetics; Reproduction; Scission; Spectroscopy; Surgical implants; Time Factors; vascular prosthesis; Viscosity
• ISSN: 1549-3296; 1552-4965; 1552-4965
• DOI: 10.1002/jbm.a.32599

Trichloroacetyl isocyanate reacts rapidly and quantitatively with both acid and hydroxyl chain ends to form derivatives that can be readily determined by 1H‐NMR spectroscopy. This method provides a convenient mean for characterization of polyethylene terephthalate (PET) end‐groups. The 1H‐NMR spectroscopy has been applied to describe the chemical aging of the PET vascular prostheses by determination of the hydroxyl and carboxyl end‐group concentrations and therefore the macromolecular weight. To validate 1H‐NMR results, we used chemical titration of the end‐groups and classical viscosimetric method as complementary techniques. The analyses made on the explants of different lifetime demonstrated a significant deterioration compared with the virgin prostheses. A high degradation of macromolecular weight is observed. This phenomenon is explained by a random scission of the ester linkages. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009