DETECTION OF DNA ADDUCTS IN DEVELOPING CD4+CD8+ THYMOCYTES AND SPLENOCYTES FOLLOWING IN UTERO EXPOSURE TO BENZO[a]PYRENE

• Published in: Immunopharmacology and immunotoxicology Vol. 24; no. 3; pp. 365 - 381
• Main Authors: Rodriguez, J. W., Kohan, M. J., King, L. C., Kirlin, W. G.
• Format: Journal Article
• Language: English
• Published: Monticello, NY Informa UK Ltd 01.01.2002; Taylor & Francis; Dekker
• Subjects: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - analysis; Animals; Benzo(a)pyrene - toxicity; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens, Environmental - toxicity; CD4 Antigens - analysis; CD8 Antigens - analysis; Chemical agents; DNA Adducts - analysis; Female; Fetus - drug effects; Humans; Immune Tolerance - drug effects; Male; Medical sciences; Mice; Mice, Inbred C3H; Neoplasms - chemically induced; Pregnancy; Smoking - adverse effects; Spleen - cytology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumors; Second trimester; Intraperitoneal administration; Thymocyte; Toxicity; Rodentia; Genotoxicity; Splenocyte; Polycyclic aromatic compound; Mutagen; In utero; Pregnancy; Carcinogen; Progeny; Vertebrata; Immunosuppression; Mammalia; Mouse; Newborn animal; Animal; DNA; Molecular adduct

ABSTRACT Environmental carcinogen exposure may play an important role in the incidence of cancer in children. In addition to environmental pollutants, maternal smoking during pregnancy may be a contributing factor. Major carcinogenic components of cigarette smoke and other combustion by-products in...