Selection of Peptide Inhibitors of Soluble Aβ1-42 Oligomer Formation by Phage Display

• Published in: Bioscience, biotechnology, and biochemistry Vol. 74; no. 11; pp. 2214 - 2219
• Main Authors: KAWASAKI, Takayasu, ONODERA, Kenji, KAMIJO, Shunsuke
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 23.11.2010; Japan Society for Bioscience Biotechnology and Agrochemistry
• Subjects: amyloid; Biological and medical sciences; fibrils; Fundamental and applied biological sciences. Psychology; phage display; soluble oligomers; Phage display; Peptides; Selection; soluble oligomers; Amyloid; Inhibitor; Oligomer; fibrils

There have been many reports suggesting that soluble oligomers of amyloid β (Aβ) are neurotoxins causing Alzheimer's disease (AD). Although inhibition of the soluble oligomerization of Aβ is considered to be effective in the treatment of AD, almost all peptide inhibitors have been designed from...