Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines

• Published in: Experimental lung research Vol. 24; no. 1; p. 3
• Main Authors: Kline, J N, Hunninghake, G M, He, B, Monick, M M, Hunninghake, G W
• Format: Journal Article
• Language: English
• Published: England 01.01.1998
• Subjects: Cytokines - pharmacology; Cytomegalovirus - genetics; Cytomegalovirus - growth & development; Cytomegalovirus - metabolism; Dinoprostone - pharmacology; Drug Synergism; Gene Expression Regulation, Viral - drug effects; Gene Expression Regulation, Viral - physiology; Genes, Immediate-Early - drug effects; Humans; Leukemia, Monocytic, Acute; Promoter Regions, Genetic - drug effects; Promoter Regions, Genetic - physiology; Transfection; Tumor Cells, Cultured; Virus Activation - drug effects; Virus Activation - physiology

Human cytomegalovirus (HCMV) is a common cause of morbidity and mortality in immunosuppressed patients, especially transplant recipients. In this population, infection is frequently due to reactivation of latent virus. The major immediate early promoter of HCMV controls production of immediate early...