Human antibody responses to bacterial antigens: studies of a model conventional antigen and a proposed model B cell superantigen

• Published in: International reviews of immunology Vol. 9; no. 1; p. 57
• Main Author: Silverman, G J
• Format: Journal Article
• Language: English
• Published: England 1992
• Subjects: Amino Acid Sequence; Antibodies, Bacterial - biosynthesis; Antibody Diversity - immunology; Antigens, Bacterial - immunology; B-Lymphocytes - immunology; Bacterial Capsules; Bacterial Vaccines - immunology; Haemophilus influenzae - immunology; Haemophilus Vaccines; Humans; Immunoglobulin Heavy Chains - immunology; Immunoglobulin Variable Region - immunology; Molecular Sequence Data; Polysaccharides, Bacterial - immunology; Staphylococcal Protein A - immunology
• ISSN: 0883-0185
• DOI: 10.3109/08830189209061783

We have investigated the human antibody repertoires that bind to two different classes of bacterial antigens. Immunization with the conventional antigen, type b capsular polysaccharide of Haemophilus influenzae Hib PS, uniformly induces IgA and IgG responses dominated by clones that use heavy chains...