Regioselective α-Alkylation of Silyl Enolates using a Mild Catalyst- ZnCl2 Doped on Acidic Alumina

• Published in: Synthetic communications Vol. 29; no. 19; pp. 3439 - 3442
• Main Authors: Kad, G. L., Singh, Vasundhara, Khurana, Anupam, Chaudhary, Sangeeta, Singh, Jasvinder
• Format: Journal Article
• Language: English
• Published: NEW YORK Taylor & Francis Group 01.01.1999; Marcel Dekker Inc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology

ZnCl 2 doped acidic alumina used as a solid support acts as a better Lewis acid in the SNl reaction of trimethyl silyl enol ethers with 3 0 , allylic and benzylic halides to yield exclusively the substituted product in excellent yields. This method has been employed for the synthesis of monocyclic s...