Leukotriene B4 enhances the activity of nuclear factor-κB pathway through BLT1 and BLT2 receptors in atherosclerosis

• Published in: Cardiovascular research Vol. 81; no. 1; pp. 216 - 225
• Main Authors: Sánchez-Galán, Eva, Gómez-Hernández, Almudena, Vidal, Cristina, Martín-Ventura, José Luis, Blanco-Colio, Luis Miguel, Muñoz-García, Begoña, Ortega, Luis, Egido, Jesús, Tuñón, José
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.2009
• Subjects: Atherosclerosis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; BLT1; BLT2; Cardiology. Vascular system; Inflammation; Leukotriene B4; Medical sciences; NF-κB; BLT1; NF-κB; Inflammation; Leukotriene B4; BLT2; Atherosclerosis; Cardiovascular disease; Activity; Phlebology; Vascular disease; Circulatory system; Transcription factor NFκB; Cardiology; Biological receptor

Aims Leukotriene B4 (LTB4) is a powerful chemoattractant and pro-inflammatory mediator in several inflammatory diseases, including atherosclerosis. It acts through its two membrane receptors, BLT1 and BLT2. The aim of this study was to determine the molecular mechanism involved in the proatherogenic...