The automated radiosynthesis and purification of the opioid receptor antagonist, [6-O-methyl-11C]diprenorphine on the GE TRACERlab FXFE radiochemistry module

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 57; no. 5; pp. 388 - 396
• Main Authors: Fairclough, Michael, Prenant, Christian, Brown, Gavin, McMahon, Adam, Lowe, Jonathan, Jones, Anthony
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 15.05.2014; Wiley Subscription Services, Inc
• Subjects: [11C]diprenorphine; automated radiosynthesis; Carbon Radioisotopes - chemistry; Diprenorphine - chemistry; Equipment Design; Isotope Labeling - instrumentation; Isotope Labeling - methods; methyl triflate; Narcotic Antagonists; opioid receptors; positron emission tomography; Positron-Emission Tomography - methods; Radiopharmaceuticals - chemical synthesis; Robotics - instrumentation; Robotics - methods; opioid receptors; automated radiosynthesis; positron emission tomography; methyl triflate; [11C]diprenorphine

[6‐O‐Methyl‐11C]diprenorphine ([11C]diprenorphine) is a positron emission tomography ligand used to probe the endogenous opioid system in vivo. Diprenorphine acts as an antagonist at all of the opioid receptor subtypes, that is, μ (mu), κ (kappa) and δ (delta). The radiosynthesis of [11C]diprenorphi...