Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain

• Published in: Annals of the New York Academy of Sciences Vol. 654; p. 33
• Main Authors: Childers, S R, Fleming, L, Konkoy, C, Marckel, D, Pacheco, M, Sexton, T, Ward, S
• Format: Journal Article
• Language: English
• Published: United States 28.06.1992
• Subjects: Adenylyl Cyclase Inhibitors; Adenylyl Imidodiphosphate - pharmacology; Analgesics - pharmacology; Animals; Brain - drug effects; Brain - enzymology; Brain - physiology; Cannabinoids - metabolism; Cannabinoids - pharmacology; Cells, Cultured; Colforsin - pharmacology; Cyclic AMP - metabolism; Enkephalin, Ala-MePhe-Gly; Enkephalin, Leucine - analogs & derivatives; Enkephalin, Leucine - pharmacology; Enkephalin, Leucine-2-Alanine - analogs & derivatives; Enkephalin, Leucine-2-Alanine - pharmacology; Enkephalins - genetics; Enkephalins - pharmacology; Male; Neurons - drug effects; Neurons - enzymology; Protein Precursors - genetics; Rats; Rats, Inbred Strains; Receptors, Cannabinoid; Receptors, Drug - drug effects; Receptors, Drug - physiology; Receptors, Opioid - drug effects; Receptors, Opioid - physiology; RNA, Messenger - metabolism

Both opioids and cannabinoids bind to G-protein-coupled receptors to inhibit adenylyl cyclase in neurons. These reactions were assayed in brain membranes, where maximal inhibitory activity occurred in the following regions: mu-opioid inhibition in rat thalamus, delta-opioid inhibition in rat striatu...