Fe3O4-Graphene oxide nanocomposite: Synthesis of 5-sulfanyl tetrazole derivatives of alkyls, indoles, and pyrroles

• Published in: Synthetic communications Vol. 48; no. 22; pp. 2888 - 2898
• Main Authors: Baghershiroudi, Mahrokh, Safa, Kazem D.
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 17.11.2018; Taylor & Francis Ltd
• Subjects: Aromatic compounds; Catalysis; Catalytic activity; Chemical synthesis; Derivatives; geraphene oxide; Graphene; heterogeneous; Indoles; Iron oxides; N-aryl pyrroles; nanocomposite; Nanocomposites; Permanent magnets; Pyrroles; sulfanyltetrazole; Tetrazoles; Thiocyanates
• DOI: 10.1080/00397911.2018.1519077
• ISSN: 0039-7911

In this work, the use of Fe 3 O 4 /geraphene oxide nanocomposite as an efficient catalyst for the synthesis of 5-sulfanyltetrazole derivatives of indoles, pyrroles, and 5-alkyl sulfanyltetrazoles is described. These compounds are readily obtained by the reaction of the starting heterocycles indoles, N-aryl pyrroles, alkyl thiocyanates, and trimethylsilyl azide in good to excellent yields. Moreover, Fe 3 O 4 /GO nanocomposite could be easily separated from the reaction mixtures by an external permanent magnet and reused at least six times continuously without significant reduction in the product yield and its catalytic activity.