Chronic Ethanol (EtOH) Consumption Differentially Alters Gray and White Matter EtOH Methyl 1H Magnetic Resonance Intensity in the Primate Brain

• Published in: Alcoholism, clinical and experimental research Vol. 37; no. 8; pp. 1325 - 1332
• Main Authors: Kroenke, Christopher D., Flory, Graham S., Park, Byung, Shaw, Jessica, Rau, Andrew R., Grant, Kathleen A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2013
• Subjects: Age; Alcohol Drinking - metabolism; Alcohol-Related Disorders - etiology; Animals; Brain - drug effects; Brain - metabolism; Central Nervous System Depressants - metabolism; Central Nervous System Depressants - pharmacology; Chronic Disease; Ethanol; Ethanol - metabolism; Ethanol - pharmacology; Gray Matter; Hydrogen; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Nonhuman Primate; Self-Administration; Self-Administration; Ethanol; Magnetic Resonance Spectroscopy; Gray Matter; Nonhuman Primate

Background In vivo magnetic resonance spectroscopy (MRS) has previously been used to directly monitor brain ethanol (EtOH). It has been proposed that the EtOH methyl 1H resonance intensity is larger in EtOH‐tolerant individuals than in sensitive individuals. To characterize the relationship between...