Simultaneous reconstruction and segmentation with the Mumford-Shah functional for electron tomography

• Published in: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Vol. 2016; pp. 5909 - 5912
• Main Authors: Li Shen, Quinto, Eric Todd, Shiqiang Wang, Ming Jiang
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01.08.2016
• Subjects: Algorithms; Computer Simulation; Electron Microscope Tomography - methods; Image edge detection; Image Processing, Computer-Assisted - methods; Image reconstruction; Inverse problems; Models, Theoretical; Scattering; Tomography; Transforms

Electron micrography (EM) is an important method for determining the three-dimensional (3D) structure of macromolecular complexes and biological specimens. But there are several limitations such as poor signal-to-noise, limitation on range of tilt angles and sub-region subject to electron exposure,...