Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones
The efficient synthesis of 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones was achieved via microwave‐assisted reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4H)‐ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type of compounds with short reaction time, high y...
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| Published in | Journal of heterocyclic chemistry Vol. 49; no. 1; pp. 59 - 63 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
01.01.2012
Wiley |
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| Abstract | The efficient synthesis of 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones was achieved via microwave‐assisted reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4H)‐ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type of compounds with short reaction time, high yields, broad substrate scope and easy operation. Besides, the synthesized compounds were subject to the test of antioxidant activity, which is represented by their capacities for scavenging 1,1‐diphenyl‐2‐picrylhydrazyl, hydroxyl and superoxide anion free radicals. Bioassay of these compounds resulted in the finding of several 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones with significant antioxidant activity. J. Heterocyclic Chem., (2012). |
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| AbstractList | The efficient synthesis of 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones was achieved via microwave‐assisted reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4H)‐ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type of compounds with short reaction time, high yields, broad substrate scope and easy operation. Besides, the synthesized compounds were subject to the test of antioxidant activity, which is represented by their capacities for scavenging 1,1‐diphenyl‐2‐picrylhydrazyl, hydroxyl and superoxide anion free radicals. Bioassay of these compounds resulted in the finding of several 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones with significant antioxidant activity. J. Heterocyclic Chem., (2012). |
| Author | Wu, Fei-Yue Shi, Feng Yan, Shu Zeng, Xiao-Ning Zheng, Wei-Fa Tu, Shu-Jiang |
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| Keywords | IRRADIATION IMIDAZOLONE DERIVATIVES SUBMERGED CULTURES ACIDS INONOTUS-OBLIQUUS UNSATURATED 2,4-DISUBSTITUTED 2-IMIDAZOLIN-5-ONES INHIBITORS ANTIMICROBIAL ACTIVITY |
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| Notes | Natural Science Foundation - No. 09KJB150011 Jiangsu Education Committee Natural Science Foundation of China - No. 21002083; No. 21072163 Interdisciplinary Key Item of Xuzhou Normal University - No. 09XKXK01 ArticleID:JHET766 istex:7864720BF84B48C5C11FEC0D7E27FA0166DBA017 ark:/67375/WNG-1B2Q863W-V These authors contributed equally to the work. Qing Lan Project - No. 08QL001 |
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| PublicationTitle | Journal of heterocyclic chemistry |
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| Snippet | The efficient synthesis of 4‐arylidene‐2‐phenyl‐1H‐imidazol‐5(4H)‐ones was achieved via microwave‐assisted reactions of... The efficient synthesis of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones was achieved via microwave-assisted reactions of... |
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| SubjectTerms | Chemistry Chemistry, Organic Physical Sciences Science & Technology |
| Title | Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones |
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