PDMS microchannel regenerative peripheral nerve interface

We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 × 110 μm 2 ) channels through which axons extend and then reconnect to the muscles on the other side of the device. Through histology and electrophysiology, we show th...

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Published in2013 6th International IEEE/EMBS Conference on Neural Engineering (NER) pp. 649 - 652
Main Authors Musick, Katherine M., Chew, Daniel J., Fawcett, James W., Lacour, Stephanie P.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.11.2013
Subjects
Animals
Electrodes
Electromyography
Implants
Microchannel
Muscles
Nerve fibers
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ISSN1948-3546
DOI10.1109/NER.2013.6696018

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Abstract We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 × 110 μm 2 ) channels through which axons extend and then reconnect to the muscles on the other side of the device. Through histology and electrophysiology, we show that axons grow through the device and functionality of the muscle control is restored. Nerve functionality as demonstrated with stimulated electromyography (EMG) recordings is still intact at 9 months after implantation. Future work on this device will include electrodes for recording and stimulating the regenerating nerve.
AbstractList We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 × 110 μm 2 ) channels through which axons extend and then reconnect to the muscles on the other side of the device. Through histology and electrophysiology, we show that axons grow through the device and functionality of the muscle control is restored. Nerve functionality as demonstrated with stimulated electromyography (EMG) recordings is still intact at 9 months after implantation. Future work on this device will include electrodes for recording and stimulating the regenerating nerve.
Author Chew, Daniel J.
Lacour, Stephanie P.
Fawcett, James W.
Musick, Katherine M.
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  givenname: Katherine M.
  surname: Musick
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  organization: Centre for Neuroprosthetics, EPFL, Lausanne, Switzerland
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  givenname: Daniel J.
  surname: Chew
  fullname: Chew, Daniel J.
  email: dc501@cam.ac.uk
  organization: Cambridge Centre for Brain Repair, Univ. of Cambridge, Cambridge, UK
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  givenname: James W.
  surname: Fawcett
  fullname: Fawcett, James W.
  organization: Cambridge Centre for Brain Repair, Univ. of Cambridge, Cambridge, UK
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  givenname: Stephanie P.
  surname: Lacour
  fullname: Lacour, Stephanie P.
  organization: Centre for Neuroprosthetics, EPFL, Lausanne, Switzerland
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Snippet We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 × 110 μm 2 ) channels...
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StartPage 649
SubjectTerms Animals
Electrodes
Electromyography
Implants
Microchannel
Muscles
Nerve fibers
Title PDMS microchannel regenerative peripheral nerve interface
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