Local antimicrobial therapy after initial periodontal treatment
Aim: The aim of this single‐blind, randomized, parallel‐designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained‐release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy. Methods: Forty‐seven patients (2...
Saved in:
| Published in | Journal of clinical periodontology Vol. 29; no. 6; pp. 540 - 550 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Munksgaard International Publishers
01.06.2002
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-6979 1600-051X |
| DOI | 10.1034/j.1600-051X.2002.290611.x |
Cover
Loading…
| Abstract | Aim: The aim of this single‐blind, randomized, parallel‐designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained‐release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy.
Methods: Forty‐seven patients (28 females and 19 males) with a mean age of 51 years (range 29–71) underwent a periodontal examination at baseline (i.e. Week 0) and after 18 weeks. This included the assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4 months prior to baseline, all subjects had received initial periodontal therapy including motivation, instruction in oral hygiene practices and full‐mouth scaling and root planing. At the treatment appointment (i.e. Week 2), the patients were randomly assigned to receive either Atridox™, Elyzol® Dental Gel or PerioChip® at all residual periodontal pockets with a probing depth ≥ 5 mm and concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol® Dental Gel was applied for a second time 7 days later. In addition to the clinical evaluation, subgingival microbiological samples were collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to evaluate changes from baseline to Week 18 for the clinical parameters.
Results: Between the baseline and 18‐week examinations, subjects treated with Atridox showed a significantly greater gain in mean PAL of 0.33 mm ± 0.09 (SD) than subjects treated with Elyzol® Dental Gel [0.03 mm ± 0.09 (SD)](p = 0.03). However, the gain in PAL of 0.16 mm ± 0.10 (SD) found after PerioChip® application did not differ significantly from that obtained following the application of AtridoxTM(p = 0.27). Of the sites treated with AtridoxTM, 42% gained ≥ 1 mm PAL and 9% ≥ 2 mm PAL as opposed to the sites treated with Elyzol® Dental Gel, in which 34% gained ≥ 1 mm PAL and 8% gained ≥ 2 mm PAL. Of the sites treated with PerioChip®, 36% gained ≥ 1 mm and 6% gained ≥ 2 mm PAL following a completed initial periodontal therapy.
Conclusions: The application of the three biodegradable sustained release devices tested following initial periodontal therapy resulted in a statistically significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for all three devices during the study period. Furthermore, when sites treated with AtridoxTM were compared with sites treated with Elyzol®, a significant difference in mean PAL gain (0.3 mm) was observed. |
|---|---|
| AbstractList | The aim of this single-blind, randomized, parallel-designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained-release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy.
Forty-seven patients (28 females and 19 males) with a mean age of 51 years (range 29-71) underwent a periodontal examination at baseline (i.e. Week 0) and after 18 weeks. This included the assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4 months prior to baseline, all subjects had received initial periodontal therapy including motivation, instruction in oral hygiene practices and full-mouth scaling and root planing. At the treatment appointment (i.e. Week 2), the patients were randomly assigned to receive either Atridox trade mark, Elyzol Dental Gel or PerioChip at all residual periodontal pockets with a probing depth >/= 5 mm and concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol Dental Gel was applied for a second time 7 days later. In addition to the clinical evaluation, subgingival microbiological samples were collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to evaluate changes from baseline to Week 18 for the clinical parameters.
Between the baseline and 18-week examinations, subjects treated with Atridox showed a significantly greater gain in mean PAL of 0.33 mm +/- 0.09 (SD) than subjects treated with Elyzol Dental Gel [0.03 mm +/- 0.09 (SD)](p = 0.03). However, the gain in PAL of 0.16 mm +/- 0.10 (SD) found after PerioChip application did not differ significantly from that obtained following the application of Atridox(p = 0.27). Of the sites treated with Atridox, 42% gained >/= 1 mm PAL and 9% >/= 2 mm PAL as opposed to the sites treated with Elyzol Dental Gel, in which 34% gained >/= 1 mm PAL and 8% gained >/= 2 mm PAL. Of the sites treated with PerioChip, 36% gained >/= 1 mm and 6% gained >/= 2 mm PAL following a completed initial periodontal therapy.
The application of the three biodegradable sustained release devices tested following initial periodontal therapy resulted in a statistically significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for all three devices during the study period. Furthermore, when sites treated with Atridox were compared with sites treated with Elyzol, a significant difference in mean PAL gain (0.3 mm) was observed. Aim: The aim of this single‐blind, randomized, parallel‐designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained‐release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy. Methods: Forty‐seven patients (28 females and 19 males) with a mean age of 51 years (range 29–71) underwent a periodontal examination at baseline (i.e. Week 0) and after 18 weeks. This included the assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4 months prior to baseline, all subjects had received initial periodontal therapy including motivation, instruction in oral hygiene practices and full‐mouth scaling and root planing. At the treatment appointment (i.e. Week 2), the patients were randomly assigned to receive either Atridox™, Elyzol® Dental Gel or PerioChip® at all residual periodontal pockets with a probing depth ≥ 5 mm and concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol® Dental Gel was applied for a second time 7 days later. In addition to the clinical evaluation, subgingival microbiological samples were collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to evaluate changes from baseline to Week 18 for the clinical parameters. Results: Between the baseline and 18‐week examinations, subjects treated with Atridox showed a significantly greater gain in mean PAL of 0.33 mm ± 0.09 (SD) than subjects treated with Elyzol® Dental Gel [0.03 mm ± 0.09 (SD)](p = 0.03). However, the gain in PAL of 0.16 mm ± 0.10 (SD) found after PerioChip® application did not differ significantly from that obtained following the application of AtridoxTM(p = 0.27). Of the sites treated with AtridoxTM, 42% gained ≥ 1 mm PAL and 9% ≥ 2 mm PAL as opposed to the sites treated with Elyzol® Dental Gel, in which 34% gained ≥ 1 mm PAL and 8% gained ≥ 2 mm PAL. Of the sites treated with PerioChip®, 36% gained ≥ 1 mm and 6% gained ≥ 2 mm PAL following a completed initial periodontal therapy. Conclusions: The application of the three biodegradable sustained release devices tested following initial periodontal therapy resulted in a statistically significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for all three devices during the study period. Furthermore, when sites treated with AtridoxTM were compared with sites treated with Elyzol®, a significant difference in mean PAL gain (0.3 mm) was observed. The aim of this single-blind, randomized, parallel-designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained-release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy.AIMThe aim of this single-blind, randomized, parallel-designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three sustained-release biodegradable polymers delivered into periodontal pockets following initial periodontal therapy.Forty-seven patients (28 females and 19 males) with a mean age of 51 years (range 29-71) underwent a periodontal examination at baseline (i.e. Week 0) and after 18 weeks. This included the assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4 months prior to baseline, all subjects had received initial periodontal therapy including motivation, instruction in oral hygiene practices and full-mouth scaling and root planing. At the treatment appointment (i.e. Week 2), the patients were randomly assigned to receive either Atridox trade mark, Elyzol Dental Gel or PerioChip at all residual periodontal pockets with a probing depth >/= 5 mm and concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol Dental Gel was applied for a second time 7 days later. In addition to the clinical evaluation, subgingival microbiological samples were collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to evaluate changes from baseline to Week 18 for the clinical parameters.METHODSForty-seven patients (28 females and 19 males) with a mean age of 51 years (range 29-71) underwent a periodontal examination at baseline (i.e. Week 0) and after 18 weeks. This included the assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4 months prior to baseline, all subjects had received initial periodontal therapy including motivation, instruction in oral hygiene practices and full-mouth scaling and root planing. At the treatment appointment (i.e. Week 2), the patients were randomly assigned to receive either Atridox trade mark, Elyzol Dental Gel or PerioChip at all residual periodontal pockets with a probing depth >/= 5 mm and concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol Dental Gel was applied for a second time 7 days later. In addition to the clinical evaluation, subgingival microbiological samples were collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to evaluate changes from baseline to Week 18 for the clinical parameters.Between the baseline and 18-week examinations, subjects treated with Atridox showed a significantly greater gain in mean PAL of 0.33 mm +/- 0.09 (SD) than subjects treated with Elyzol Dental Gel [0.03 mm +/- 0.09 (SD)](p = 0.03). However, the gain in PAL of 0.16 mm +/- 0.10 (SD) found after PerioChip application did not differ significantly from that obtained following the application of Atridox(p = 0.27). Of the sites treated with Atridox, 42% gained >/= 1 mm PAL and 9% >/= 2 mm PAL as opposed to the sites treated with Elyzol Dental Gel, in which 34% gained >/= 1 mm PAL and 8% gained >/= 2 mm PAL. Of the sites treated with PerioChip, 36% gained >/= 1 mm and 6% gained >/= 2 mm PAL following a completed initial periodontal therapy.RESULTSBetween the baseline and 18-week examinations, subjects treated with Atridox showed a significantly greater gain in mean PAL of 0.33 mm +/- 0.09 (SD) than subjects treated with Elyzol Dental Gel [0.03 mm +/- 0.09 (SD)](p = 0.03). However, the gain in PAL of 0.16 mm +/- 0.10 (SD) found after PerioChip application did not differ significantly from that obtained following the application of Atridox(p = 0.27). Of the sites treated with Atridox, 42% gained >/= 1 mm PAL and 9% >/= 2 mm PAL as opposed to the sites treated with Elyzol Dental Gel, in which 34% gained >/= 1 mm PAL and 8% gained >/= 2 mm PAL. Of the sites treated with PerioChip, 36% gained >/= 1 mm and 6% gained >/= 2 mm PAL following a completed initial periodontal therapy.The application of the three biodegradable sustained release devices tested following initial periodontal therapy resulted in a statistically significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for all three devices during the study period. Furthermore, when sites treated with Atridox were compared with sites treated with Elyzol, a significant difference in mean PAL gain (0.3 mm) was observed.CONCLUSIONSThe application of the three biodegradable sustained release devices tested following initial periodontal therapy resulted in a statistically significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for all three devices during the study period. Furthermore, when sites treated with Atridox were compared with sites treated with Elyzol, a significant difference in mean PAL gain (0.3 mm) was observed. |
| Author | Rutar, Alexandra Suvan, Jean Garrett, Steven Salvi, Giovanni E. Mombelli, Andrea Lang, Niklaus P. Mayfield, Lisa |
| Author_xml | – sequence: 1 givenname: Giovanni E. surname: Salvi fullname: Salvi, Giovanni E. organization: University of Berne, School of Dental Medicine, Berne – sequence: 2 givenname: Andrea surname: Mombelli fullname: Mombelli, Andrea organization: University of Geneva, School of Dental Medicine, Geneva, Switzerland – sequence: 3 givenname: Lisa surname: Mayfield fullname: Mayfield, Lisa organization: University of Berne, School of Dental Medicine, Berne – sequence: 4 givenname: Alexandra surname: Rutar fullname: Rutar, Alexandra organization: University of Berne, School of Dental Medicine, Berne – sequence: 5 givenname: Jean surname: Suvan fullname: Suvan, Jean organization: Eastman Dental Institute, University College London, London, UK – sequence: 6 givenname: Steven surname: Garrett fullname: Garrett, Steven organization: Atrix Laboratories Inc., Fort Collins, Colorado, USA – sequence: 7 givenname: Niklaus P. surname: Lang fullname: Lang, Niklaus P. organization: University of Berne, School of Dental Medicine, Berne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12296782$$D View this record in MEDLINE/PubMed |
| BookMark | eNpFkF1LwzAUhoMouql_QeaNd60nSZsuV6JDN6XoBEXvwlmaYmY_Zprh9u9tqc6rwznn4YX3GZL9qq4MIecUQgo8ulyGVAAEENP3kAGwkEkQlIabPTLYffbJADjwQMhEHpFh0ywBaMI5PyRHlDEpkjEbkKu01liMsPK2tNrVC9tu_sM4XG1HmHvjRrayvruujLN1Vle-I5xBX5rKn5CDHIvGnP7OY_J6d_symQXp0_R-cp0GllFBgygxVOsFlTJGBIgzMdZaohS4iOKERu0hB5rFsYhlzvK2AwBSZIgaxxoMPyYXfe7K1V9r03hV2kabosDK1OtGJazrJFkLnv2C60VpMrVytkS3VX-VW-C6B75tYbb_f1CdW7VUnUHVGVSdW9W7VRv1MJnf9kubEfQZtvFms8tA96lEwpNYvT1O1XM0nc9Seqdu-A9K_n6Z |
| ContentType | Journal Article |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1034/j.1600-051X.2002.290611.x |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1600-051X |
| EndPage | 550 |
| ExternalDocumentID | 12296782 JCPE290611 ark_67375_WNG_Q4GPHL1F_B |
| Genre | article Comparative Study Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 1OB 1OC 29K 31~ 33P 34H 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAWTL AAXRX AAZKR ABCQN ABCUV ABEML ABJNI ABLJU ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFZJQ AHBTC AHEFC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 CWXXS D-E D-F D-I DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.T H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 UMD V8K V9Y W8V W99 WBKPD WBNRW WIH WIJ WIK WOHZO WPGGZ WQJ WRC WXSBR XG1 YFH YOC YOJ YUY ZGI ZXP ZZTAW ~IA ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACYXJ ADNMO AFWVQ ALVPJ CGR CUY CVF ECM EIF NPM PKN 7X8 AAMMB AEFGJ AEYWJ AGQPQ AGXDD AGYGG AIDQK AIDYY |
| ID | FETCH-LOGICAL-i2161-47e1ccb1995aa005d68cc9a96ab457145d6f01d55659f2f60000a1a2aaca8c0e3 |
| IEDL.DBID | DR2 |
| ISSN | 0303-6979 |
| IngestDate | Fri Jul 11 05:10:34 EDT 2025 Wed Feb 19 02:34:41 EST 2025 Wed Jan 22 17:03:55 EST 2025 Wed Oct 30 09:51:20 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-i2161-47e1ccb1995aa005d68cc9a96ab457145d6f01d55659f2f60000a1a2aaca8c0e3 |
| Notes | ArticleID:110 istex:348F4DEE3E0B42259A399632C36CE19B0B6E90E1 ark:/67375/WNG-Q4GPHL1F-B ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| PMID | 12296782 |
| PQID | 72122992 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_72122992 pubmed_primary_12296782 wiley_primary_10_1034_j_1600_051X_2002_290611_x_JCPE290611 istex_primary_ark_67375_WNG_Q4GPHL1F_B |
| PublicationCentury | 2000 |
| PublicationDate | 2002-06 June 2002 2002-Jun 20020601 |
| PublicationDateYYYYMMDD | 2002-06-01 |
| PublicationDate_xml | – month: 06 year: 2002 text: 2002-06 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: United States |
| PublicationTitle | Journal of clinical periodontology |
| PublicationTitleAlternate | J Clin Periodontol |
| PublicationYear | 2002 |
| Publisher | Munksgaard International Publishers |
| Publisher_xml | – name: Munksgaard International Publishers |
| References | Kinane, D. F. & Radvar, M. (1999) A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. Journal of Periodontology 70, 1-7. Polson, A. M., Garrett, S., Stoller, N. H., Bandt, C. L., Hanes, P. J., Killoy, W. J., Southard, G. L. , Duke, S. P., Bogle, G. C., Drisko, C. H. & Friesen, L. R. (1997) Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. Journal of Periodontology 68, 119-126. Badersten, A., Nilvéus, R. & Egelberg, J. (1981) Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. Journal of Clinical Periodontology 8, 57-72. Westfelt, E., Bragd, L., Socransky, S. S., Haffajee, A. D., Nyman, S. & Lindhe, J. (1985) Improved periodontal conditions following therapy. Journal of Clinical Periodontology 12, 283-293. Syed, S. A., Svanberg, M. & Svanberg, G. (1980) The predominant cultivable dental plaque flora of beagle dogs with gingivitis. Journal of Periodontal Research 15, 123-136. Zambon, J. J. (1996) Periodontal diseases: Microbial factors. Annals of Periodontology 1, 879-925. Morrison, E. C., Ramfjord, S. P. & Hill, R. W. (1980) Short-term effects of initial, nonsurgical periodontal treatment (hygienic phase). Journal of Clinical Periodontology 7, 199-211. Radvar, M., Pourtaghi, N. & Kinane, D. F. (1996) Comparison of 3 periodontal local antibiotic therapies in persistent periodontal pockets. Journal of Periodontology 67, 860-865. Keller, W., Brägger, U. & Mombelli, A. (1998) Peri-implant microflora of implants with cemented and screw retained suprastructures. Clinical Oral Implants Research 9, 209-217. Loos, B., Claffey, N. & Crigger, M. (1988) Effects of oral hygiene measures on clinical and microbiological prameters of periodontal disease. Journal of Clinical Periodontology 15, 211-216. Offenbacher, S. (1996) Periodontal diseases: pathogenesis. Annals of Periodontology 1, 821-878. Garrett, S., Johnson, L., Drisko, C. H., Adams, D. F., Bandt, C. L., Beiswanger, B., Bogle, G. (1999) Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene and scaling and root planing in the treatment of periodontitis. Journal of Periodontology 70, 490-503. Ainamo, J., Lie, T., Ellingsen, B. H., Hansen, B. F., Johansson, L. A., Karring, T., Kisch, J. , Paunio, K. & Stoltae, K.(1992) Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. Journal of Clinical Periodontology 19, 723-729. Palcanis, K. G. (1996) Surgical pocket therapy. Annals of Periodontology 1, 589-617. Lie, T., Bruun, G. & Boe, O. E. (1998) Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. Journal of Periodontology 69, 819-827. Silness, J. & Löe, H. (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 22, 121-135. Stelzel, M., Flores, -de & Jacoby, L. (1997) Topical metronidazole application in recall patients. Long-term results. Journal of Clinical Periodontology 24, 914-919. Pihlstrom, B. L., McHugh, R. B., Oliphant, T. H. & Ortiz-Campos, C. (1983) Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 6, 1/2 years. Journal of Clinical Periodontology 10, 524-541. Stoltze, K. (1995) Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets. Journal of Clinical Periodontology 22, 185-187. Badersten, A., Nilvéus, R. & Egelberg, J. (1984) Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology 11, 63-76. Pedrazzoli, V., Kilian, M. & Karring, T. (1992) Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. Journal of Clinical Periodontology 19, 715-722. Riep, B., Purucker, P. & Bernimoulin, J. P. (1999) Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients. Journal of Clinical Periodontology 26, 710-715. Sbordone, L., Ramaglia, L., Gulletta, E. & Iacono, V. (1990) Recolonization of the subgingival microflora after scaling and root planing in human periodontitis. Journal of Periodontology 61, 579-584. Soskolne, W. A., Heasman, P. A., Stabholz, A., Smart, G. J., Palmer, M., Flashner, M. & Newman, H. N. (1997) Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. Journal of Periodontology 68, 32-38. Greenstein, G. & Polson, A. (1998) The role of local drug delivery in the management of periodontal diseases: a comprehensive review. Journal of Periodontology 69, 507-520. Klinge, B., Attström, R., Karring, T., Kisch, J., Lewin, B. & Stoltze, K. (1992) Three regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. Journal of Clinical Periodontology 19, 708-714. Mousquès, T., Listgarten, M. A. & Phillips, R. W. (1980) Effect of scaling and root planing on the composition of the human subgingival microbial flora. Journal of Periodontal Research 15, 144-151. Rudhart, A., Purucker, P., Kage, A., Hopfenmüller, W. & Bernimoulin, J. P. (1998) Local metronidazole application in maintenance patients. Clinical and microbiological evaluation. Journal of Periodontology 69, 1148-1154. Hill, R. W., Ramfjord, S. P., Morrison, E. C., Appleberry, E. A., Caffesse, R. G., Kerry, G. J. & Nissle, R. R. (1981) Four types of periodontal treatment compared over two years. Journal of Periodontology 52, 655-662. Stelzel, M., Flores-de-Jacoby, L. (1996) Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. Journal of Clinical Periodontologyl 23, 24-29. Garrett, S., Adams, D. F., Bogle, G., Donly, K., Drisko, C. H., Hallmon, W. W., Hancock, E. B., Hanes, P., Hawley, C. E., Johnson, L., Kiger, R., Killoy, W., Mellonig, J. T., Raab, F. J., Ryder, M., Stoller, N., Polson, A., Wang, H. L., Wolinsky, L. E., Yukna, R. A., Harrold, C. Q., Hill, M., Johnson, V. B. & Southard, G. L., (2000) The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months. Journal of Periodontology 71, 22-30. Magnusson, I., Lindhe, J., Yoneyama, T. & Liljenberg, B. (1984) Recolonization of a subgingival microbiota following scaling in deep pockets. Journal of Clinical Periodontology 11, 193-207. Stoltze, K. (1992) Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. Journal of Clinical Periodontology 19, 698-701. Jeffcoat, M. K., Bray, K. S., Ciancio, S. G., Dentino, A. R., Fine, D. H., Gordon, J. M., Gunsolley, J. C., Killoy, W. J., Lowenguth, R. A., Magnusson, N. I., Offenbacher, S., Palcanis, K. G., Proskin, H. M., Finkelman, R. D. & Flashner, M. (1998) Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. Journal of Periodontology 69, 989-997. Rams, T. E. & Slots, J. (1996) Local delivery of antimicrobial agents in the periodontal pocket. Periodontology 2000 10, 139-159. Noyan, U., Yilmaz, S., Kuru, B., Kadir, T., Acar, O. & Buget, E. (1997) A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. Journal of Clinical Periodontology 24, 158-165. Slots, J. (1982) Selective medium for isolation of Actinobacillus actinimycetemcomitans. Journal of Clinical Microbiology 15, 606-609. 1980; 15 1982; 15 1984; 11 1988; 15 1997; 24 1997; 68 1999; 26 1995; 22 1983; 10 1964; 22 1992; 19 1981; 8 2000; 71 1980; 7 1996; 1 1999; 70 1985; 12 1981; 52 1996; 10 1998; 69 1998; 9 1996; 67 1996; 23 1990; 61 |
| References_xml | – reference: Stelzel, M., Flores, -de & Jacoby, L. (1997) Topical metronidazole application in recall patients. Long-term results. Journal of Clinical Periodontology 24, 914-919. – reference: Magnusson, I., Lindhe, J., Yoneyama, T. & Liljenberg, B. (1984) Recolonization of a subgingival microbiota following scaling in deep pockets. Journal of Clinical Periodontology 11, 193-207. – reference: Zambon, J. J. (1996) Periodontal diseases: Microbial factors. Annals of Periodontology 1, 879-925. – reference: Pihlstrom, B. L., McHugh, R. B., Oliphant, T. H. & Ortiz-Campos, C. (1983) Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 6, 1/2 years. Journal of Clinical Periodontology 10, 524-541. – reference: Sbordone, L., Ramaglia, L., Gulletta, E. & Iacono, V. (1990) Recolonization of the subgingival microflora after scaling and root planing in human periodontitis. Journal of Periodontology 61, 579-584. – reference: Hill, R. W., Ramfjord, S. P., Morrison, E. C., Appleberry, E. A., Caffesse, R. G., Kerry, G. J. & Nissle, R. R. (1981) Four types of periodontal treatment compared over two years. Journal of Periodontology 52, 655-662. – reference: Riep, B., Purucker, P. & Bernimoulin, J. P. (1999) Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients. Journal of Clinical Periodontology 26, 710-715. – reference: Rudhart, A., Purucker, P., Kage, A., Hopfenmüller, W. & Bernimoulin, J. P. (1998) Local metronidazole application in maintenance patients. Clinical and microbiological evaluation. Journal of Periodontology 69, 1148-1154. – reference: Stoltze, K. (1992) Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel. Journal of Clinical Periodontology 19, 698-701. – reference: Palcanis, K. G. (1996) Surgical pocket therapy. Annals of Periodontology 1, 589-617. – reference: Loos, B., Claffey, N. & Crigger, M. (1988) Effects of oral hygiene measures on clinical and microbiological prameters of periodontal disease. Journal of Clinical Periodontology 15, 211-216. – reference: Kinane, D. F. & Radvar, M. (1999) A six-month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets. Journal of Periodontology 70, 1-7. – reference: Klinge, B., Attström, R., Karring, T., Kisch, J., Lewin, B. & Stoltze, K. (1992) Three regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. Journal of Clinical Periodontology 19, 708-714. – reference: Greenstein, G. & Polson, A. (1998) The role of local drug delivery in the management of periodontal diseases: a comprehensive review. Journal of Periodontology 69, 507-520. – reference: Badersten, A., Nilvéus, R. & Egelberg, J. (1984) Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis. Journal of Clinical Periodontology 11, 63-76. – reference: Badersten, A., Nilvéus, R. & Egelberg, J. (1981) Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. Journal of Clinical Periodontology 8, 57-72. – reference: Lie, T., Bruun, G. & Boe, O. E. (1998) Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. Journal of Periodontology 69, 819-827. – reference: Garrett, S., Johnson, L., Drisko, C. H., Adams, D. F., Bandt, C. L., Beiswanger, B., Bogle, G. (1999) Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene and scaling and root planing in the treatment of periodontitis. Journal of Periodontology 70, 490-503. – reference: Rams, T. E. & Slots, J. (1996) Local delivery of antimicrobial agents in the periodontal pocket. Periodontology 2000 10, 139-159. – reference: Westfelt, E., Bragd, L., Socransky, S. S., Haffajee, A. D., Nyman, S. & Lindhe, J. (1985) Improved periodontal conditions following therapy. Journal of Clinical Periodontology 12, 283-293. – reference: Syed, S. A., Svanberg, M. & Svanberg, G. (1980) The predominant cultivable dental plaque flora of beagle dogs with gingivitis. Journal of Periodontal Research 15, 123-136. – reference: Stelzel, M., Flores-de-Jacoby, L. (1996) Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients. Journal of Clinical Periodontologyl 23, 24-29. – reference: Silness, J. & Löe, H. (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinavica 22, 121-135. – reference: Stoltze, K. (1995) Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets. Journal of Clinical Periodontology 22, 185-187. – reference: Offenbacher, S. (1996) Periodontal diseases: pathogenesis. Annals of Periodontology 1, 821-878. – reference: Morrison, E. C., Ramfjord, S. P. & Hill, R. W. (1980) Short-term effects of initial, nonsurgical periodontal treatment (hygienic phase). Journal of Clinical Periodontology 7, 199-211. – reference: Slots, J. (1982) Selective medium for isolation of Actinobacillus actinimycetemcomitans. Journal of Clinical Microbiology 15, 606-609. – reference: Noyan, U., Yilmaz, S., Kuru, B., Kadir, T., Acar, O. & Buget, E. (1997) A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. Journal of Clinical Periodontology 24, 158-165. – reference: Garrett, S., Adams, D. F., Bogle, G., Donly, K., Drisko, C. H., Hallmon, W. W., Hancock, E. B., Hanes, P., Hawley, C. E., Johnson, L., Kiger, R., Killoy, W., Mellonig, J. T., Raab, F. J., Ryder, M., Stoller, N., Polson, A., Wang, H. L., Wolinsky, L. E., Yukna, R. A., Harrold, C. Q., Hill, M., Johnson, V. B. & Southard, G. L., (2000) The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months. Journal of Periodontology 71, 22-30. – reference: Radvar, M., Pourtaghi, N. & Kinane, D. F. (1996) Comparison of 3 periodontal local antibiotic therapies in persistent periodontal pockets. Journal of Periodontology 67, 860-865. – reference: Keller, W., Brägger, U. & Mombelli, A. (1998) Peri-implant microflora of implants with cemented and screw retained suprastructures. Clinical Oral Implants Research 9, 209-217. – reference: Pedrazzoli, V., Kilian, M. & Karring, T. (1992) Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. Journal of Clinical Periodontology 19, 715-722. – reference: Polson, A. M., Garrett, S., Stoller, N. H., Bandt, C. L., Hanes, P. J., Killoy, W. J., Southard, G. L. , Duke, S. P., Bogle, G. C., Drisko, C. H. & Friesen, L. R. (1997) Multi-center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. Journal of Periodontology 68, 119-126. – reference: Ainamo, J., Lie, T., Ellingsen, B. H., Hansen, B. F., Johansson, L. A., Karring, T., Kisch, J. , Paunio, K. & Stoltae, K.(1992) Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. Journal of Clinical Periodontology 19, 723-729. – reference: Mousquès, T., Listgarten, M. A. & Phillips, R. W. (1980) Effect of scaling and root planing on the composition of the human subgingival microbial flora. Journal of Periodontal Research 15, 144-151. – reference: Jeffcoat, M. K., Bray, K. S., Ciancio, S. G., Dentino, A. R., Fine, D. H., Gordon, J. M., Gunsolley, J. C., Killoy, W. J., Lowenguth, R. A., Magnusson, N. I., Offenbacher, S., Palcanis, K. G., Proskin, H. M., Finkelman, R. D. & Flashner, M. (1998) Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. Journal of Periodontology 69, 989-997. – reference: Soskolne, W. A., Heasman, P. A., Stabholz, A., Smart, G. J., Palmer, M., Flashner, M. & Newman, H. N. (1997) Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. Journal of Periodontology 68, 32-38. – volume: 69 start-page: 1148 year: 1998 end-page: 1154 article-title: Local metronidazole application in maintenance patients. Clinical and microbiological evaluation publication-title: Journal of Periodontology – volume: 52 start-page: 655 year: 1981 end-page: 662 article-title: Four types of periodontal treatment compared over two years publication-title: Journal of Periodontology – volume: 68 start-page: 119 year: 1997 end-page: 126 article-title: Multi‐center comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results publication-title: Journal of Periodontology – volume: 69 start-page: 819 year: 1998 end-page: 827 article-title: Effects of topical metronidazole and tetracycline in treatment of adult periodontitis publication-title: Journal of Periodontology – volume: 22 start-page: 121 year: 1964 end-page: 135 article-title: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition publication-title: Acta Odontologica Scandinavica – volume: 9 start-page: 209 year: 1998 end-page: 217 article-title: Peri‐implant microflora of implants with cemented and screw retained suprastructures publication-title: Clinical Oral Implants Research – volume: 15 start-page: 211 year: 1988 end-page: 216 article-title: Effects of oral hygiene measures on clinical and microbiological prameters of periodontal disease publication-title: Journal of Clinical Periodontology – volume: 61 start-page: 579 year: 1990 end-page: 584 article-title: Recolonization of the subgingival microflora after scaling and root planing in human periodontitis publication-title: Journal of Periodontology – volume: 10 start-page: 524 year: 1983 end-page: 541 article-title: Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 6, 1/2 years publication-title: Journal of Clinical Periodontology – volume: 15 start-page: 606 year: 1982 end-page: 609 article-title: Selective medium for isolation of publication-title: Journal of Clinical Microbiology – volume: 23 start-page: 24 year: 1996 end-page: 29 article-title: Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients publication-title: Journal of Clinical Periodontologyl – volume: 70 start-page: 1 year: 1999 end-page: 7 article-title: A six‐month comparison of three periodontal local antimicrobial therapies in persistent periodontal pockets publication-title: Journal of Periodontology – volume: 10 start-page: 139 year: 1996 end-page: 159 article-title: Local delivery of antimicrobial agents in the periodontal pocket publication-title: Periodontology 2000 – volume: 1 start-page: 821 year: 1996 end-page: 878 article-title: Periodontal diseases: pathogenesis publication-title: Annals of Periodontology – volume: 24 start-page: 158 year: 1997 end-page: 165 article-title: A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients publication-title: Journal of Clinical Periodontology – volume: 11 start-page: 63 year: 1984 end-page: 76 article-title: Effect of nonsurgical periodontal therapy. II. Severely advanced periodontitis publication-title: Journal of Clinical Periodontology – volume: 71 start-page: 22 year: 2000 end-page: 30 article-title: The effect of locally delivered controlled‐release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months publication-title: Journal of Periodontology – volume: 19 start-page: 698 year: 1992 end-page: 701 article-title: Concentration of metronidazole in periodontal pockets after application of a metronidazole 25% dental gel publication-title: Journal of Clinical Periodontology – volume: 26 start-page: 710 year: 1999 end-page: 715 article-title: Repeated local metronidazole‐therapy as adjunct to scaling and root planing in maintenance patients publication-title: Journal of Clinical Periodontology – volume: 19 start-page: 715 year: 1992 end-page: 722 article-title: Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis publication-title: Journal of Clinical Periodontology – volume: 67 start-page: 860 year: 1996 end-page: 865 article-title: Comparison of 3 periodontal local antibiotic therapies in persistent periodontal pockets publication-title: Journal of Periodontology – volume: 1 start-page: 879 year: 1996 end-page: 925 article-title: Periodontal diseases: Microbial factors publication-title: Annals of Periodontology – volume: 24 start-page: 914 year: 1997 end-page: 919 article-title: Topical metronidazole application in recall patients. Long‐term results publication-title: Journal of Clinical Periodontology – volume: 7 start-page: 199 year: 1980 end-page: 211 article-title: Short‐term effects of initial, nonsurgical periodontal treatment (hygienic phase) publication-title: Journal of Clinical Periodontology – volume: 11 start-page: 193 year: 1984 end-page: 207 article-title: Recolonization of a subgingival microbiota following scaling in deep pockets publication-title: Journal of Clinical Periodontology – volume: 69 start-page: 507 year: 1998 end-page: 520 article-title: The role of local drug delivery in the management of periodontal diseases: a comprehensive review publication-title: Journal of Periodontology – volume: 1 start-page: 589 year: 1996 end-page: 617 article-title: Surgical pocket therapy publication-title: Annals of Periodontology – volume: 8 start-page: 57 year: 1981 end-page: 72 article-title: Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis publication-title: Journal of Clinical Periodontology – volume: 12 start-page: 283 year: 1985 end-page: 293 article-title: Improved periodontal conditions following therapy publication-title: Journal of Clinical Periodontology – volume: 19 start-page: 708 year: 1992 end-page: 714 article-title: Three regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults publication-title: Journal of Clinical Periodontology – volume: 22 start-page: 185 year: 1995 end-page: 187 article-title: Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets publication-title: Journal of Clinical Periodontology – volume: 19 start-page: 723 year: 1992 end-page: 729 article-title: Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis publication-title: Journal of Clinical Periodontology – volume: 70 start-page: 490 year: 1999 end-page: 503 article-title: Two multi‐center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene and scaling and root planing in the treatment of periodontitis publication-title: Journal of Periodontology – volume: 15 start-page: 144 year: 1980 end-page: 151 article-title: Effect of scaling and root planing on the composition of the human subgingival microbial flora publication-title: Journal of Periodontal Research – volume: 15 start-page: 123 year: 1980 end-page: 136 article-title: The predominant cultivable dental plaque flora of beagle dogs with gingivitis publication-title: Journal of Periodontal Research – volume: 69 start-page: 989 year: 1998 end-page: 997 article-title: Adjunctive use of a subgingival controlled‐release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone publication-title: Journal of Periodontology – volume: 68 start-page: 32 year: 1997 end-page: 38 article-title: Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi‐center study publication-title: Journal of Periodontology |
| SSID | ssj0017333 |
| Score | 1.6446853 |
| Snippet | Aim: The aim of this single‐blind, randomized, parallel‐designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three... The aim of this single-blind, randomized, parallel-designed clinical trial (RCT) was to evaluate the clinical and microbiological effects of three... |
| SourceID | proquest pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 540 |
| SubjectTerms | Adult Aged Aggregatibacter actinomycetemcomitans - growth & development Analysis of Variance Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - therapeutic use biodegradable drug delivery systems Biodegradation, Environmental Chlorhexidine - administration & dosage Chlorhexidine - analogs & derivatives Chlorhexidine - therapeutic use Colony Count, Microbial Delayed-Action Preparations Dental Plaque Index Doxycycline - administration & dosage Doxycycline - analogs & derivatives Doxycycline - therapeutic use Female Follow-Up Studies Fusobacterium - growth & development Gingival Hemorrhage - drug therapy Glycerides - administration & dosage Glycerides - therapeutic use Humans Male Metronidazole - administration & dosage Metronidazole - analogs & derivatives Metronidazole - therapeutic use microbiological effects Middle Aged Periodontal Attachment Loss - drug therapy periodontal disease Periodontal Pocket - drug therapy Periodontal Pocket - microbiology periodontal therapy Periodontitis - drug therapy Periodontitis - microbiology Porphyromonas - growth & development Prevotella - growth & development randomized clinical trial (RCT) Sesame Oil - administration & dosage Sesame Oil - therapeutic use Single-Blind Method Treatment Outcome |
| Title | Local antimicrobial therapy after initial periodontal treatment |
| URI | https://api.istex.fr/ark:/67375/WNG-Q4GPHL1F-B/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1034%2Fj.1600-051X.2002.290611.x https://www.ncbi.nlm.nih.gov/pubmed/12296782 https://www.proquest.com/docview/72122992 |
| Volume | 29 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3JTsMwELUQB-DCvpQ1SIhbCnYcp-GC2NqqgqogEL1ZjutIUaFFXaTC1zNjhyAQnOAYO7Fij8fzbM_MI-TAMGY0-oWBaer43AShryqC-hEXKRVaR7HBc8ibpqg_8EY7bOd0QBgL4_JDFAduqBl2vUYFV8kwDxPnTskFRkWHtG09DcqYuJzSMgJK9N1CgHRXpJKiUeBo5WHJ9kUcxTNkP2_r6NeWALDiWE9-Qp9fway1RtUF8vTRD-eE0i2PR0lZv31L8fhPHV0k8zlq9c7cNFsiU6a3TGYv0dMIyeJWyOk12kQPxJQ9Zza3Ezy52K5Xz_KQexm6KUEpplaGvTBGYXqFm_sqeahe3V_U_Zybwc8YgESfR4ZqnWCAt1KgyR1R0TpWsVAJDyPKoSA9pp0Q8GKcslSgXVRUMaW0quhjE6yR6V6_ZzaIZ5hIBRImRYHmYaASlXaCNNZGw8tpqEvk0EpBvrj8G1INuuiOFoXysVmTt7zWql_Tqjwvkb0PMUlQErz5UD3THw8lbHMZ2F1WIutOekVbWA72GmpOrAw-K_ByPuC4OYKflzj6SNnJpBt9OZGNi9aVe9j8y8dbZM4yzNiTnW0yPRqMzQ4AnVGya2fwO6wr7xE |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT8MwDLYQSMCF92M8i4S4dSxpmq5cEK8xYEyAQOwWpVkqTYiBYJOAX4-dlCEQnODYpI2aOI4_O34AbFrOrSG_MBRN7VDYKA51VbIwETJn0pgktWSHPG_K-o04bcWtIjyaYmF8foiBwY04w53XxOBkkC7ixIXncklh0TFrOVeDMmUuZ6yMiHKEKnw7BetqkEyKJZEvLI-HdijTJB2FjWKw7V-HQshKq_3yE_78CmedPKpNwv3HTLwbyl2538vK5u1bksf_muoUTBTANdjzO20ahmx3BsYOydmI6sXNwm6DxGKAlOrcd1x6J3zy4V2vgStFHnTIUwlbKbsyqsMUiBkMPN3n4KZ2dH1QD4vyDGGHI04MRWKZMRnFeGuNzNyWVWNSnUqdiThhAhvyCmvHCBnTnOeSRKNmmmttdNVUbDQPw92Hrl2EwHKZS6qZlERGxJHOdN6O8tRYgy_nsSnBliODevQpOJR-uiOPtCRWt81jdSmOL-oNVlP7JVj_oJNCPqHLD921D_1nhZouR9HLS7DgyTcYi9pRZGPPjiPCZwfdz0eC9CP8eUWrT1U7ufKrr17U6cHFkX9Y-svH6zBWvz5vqMZJ82wZxl3BGWfoWYHh3lPfriLu6WVrbju_A7O18yw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fT9swED5NIMFeYD8YFLYRpIm3dLXjOA0vCCilg1IVBFrfLMexpapQELQS8NdzZ4dOQ9vT9hg7sWKfz_fZvrsP4Jvl3BryC0PTVMbCJmmsm5LFmZCOSWOy3NI55GlPdi7F8SAdVHRAFAsT8kPMDtxIM_x6TQp-W7oqTFwEJZcUFZ2ygfc0qFPicsbqCCjnhWw0aYq3zme5pFiWBF55XLNjmWf5AmxVjX3_a1OIWGmwH_4EP39Hs94ctZfh6qUjwQtlVJ9Oirp5epXj8T_19B0sVbA12gvz7D28seMPsNgiVyNii_sIu10yihHKaXg99Mmd8CkEdz1Gnog8GpKfEpZSbmXcDFMYZjTzc1-By_bhxUEnrsgZ4iFHlBiLzDJjCorw1hpVuZRNY3KdS12INGMCC1yDlSkCxtxxJ8kwaqa51kY3TcMmn2BufDO2axBZLp0kxqQsMSJNdKFdmbjcWIMvu9TUYNtLQd2GBBxK343IHy1L1c_ekToTR_1Ol7XVfg02X8SkUEvo6kOP7c30XuE-l6Ph5TVYDdKbtUXlaLCxZsfL4FcF3c4ngnZH-POKRp84O7kKo68e1PFB_zA8rP_Lx5uw0G-1VfdH72QD3nq2GX_K8xnmJndT-wVBz6T46ifzM_D18eQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Local+antimicrobial+therapy+after+initial+periodontal+treatment&rft.jtitle=Journal+of+clinical+periodontology&rft.au=Salvi%2C+Giovanni+E&rft.au=Mombelli%2C+Andrea&rft.au=Mayfield%2C+Lisa&rft.au=Rutar%2C+Alexandra&rft.date=2002-06-01&rft.issn=0303-6979&rft.volume=29&rft.issue=6&rft.spage=540&rft_id=info:doi/10.1034%2Fj.1600-051x.2002.290611.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0303-6979&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0303-6979&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0303-6979&client=summon |