Sonogashira, CuAAC, and Oxime Ligations for the Synthesis of MnI Tricarbonyl PhotoCORM Peptide Conjugates

• Published in: European journal of inorganic chemistry Vol. 2014; no. 18; pp. 2886 - 2895
• Main Authors: Pai, Sandesh, Radacki, Krzysztof, Schatzschneider, Ulrich
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.06.2014; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Alkynes; Bioinorganic chemistry; Bioorthogonal coupling; Carbonyl ligands; CO release; Conjugates; Conjugation; Freeze thaw cycles; Growth factors; Manganese; Myoglobins; Peptides

In this work, facial tricarbonylmanganese(I) complexes [Mn(bpeaCH2C6H4R)(CO)3]PF6 incorporating a functionalized 2,2‐bis(pyrazolyl)ethylamine (bpea) ligand with R = I, C≡CH, and CHO have been explored for their utility in bioorthogonal coupling to carrier peptides bearing N‐terminal alkyne, azide, a...