Influence of age on BDNF modulation of hippocampal synaptic transmission: Interplay with adenosine A2A receptors

• Published in: Hippocampus Vol. 17; no. 7; pp. 577 - 585
• Main Authors: Diógenes, Maria J., Assaife-Lopes, Natália, Pinto-Duarte, António, Ribeiro, Joaquim A., Sebastião, Ana M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2007
• Subjects: A2A receptors; adenosine; Adenosine - metabolism; Adenosine A2 Receptor Agonists; aging; Aging - physiology; Animals; BDNF; Binding, Competitive - physiology; Brain-Derived Neurotrophic Factor - metabolism; Brain-Derived Neurotrophic Factor - pharmacology; Down-Regulation - drug effects; Down-Regulation - physiology; Excitatory Postsynaptic Potentials - drug effects; Excitatory Postsynaptic Potentials - physiology; Hippocampus - drug effects; Hippocampus - growth & development; Hippocampus - metabolism; Male; Neural Pathways - drug effects; Neural Pathways - growth & development; Neural Pathways - metabolism; Organ Culture Techniques; Presynaptic Terminals - metabolism; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A2A - metabolism; Receptor, trkB - agonists; Receptor, trkB - metabolism; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; TrkB receptors; Up-Regulation - drug effects; Up-Regulation - physiology

We previously reported that adenosine, through A2A receptor activation, potentiates synaptic actions of brain‐derived neurotrophic factor (BDNF) in the hippocampus of infant (3–4 weeks) rats. Since A2A‐receptor‐mediated actions are more evident in old than in young rats and since the therapeutic pot...