Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3

• Published in: Journal of cellular biochemistry Vol. 88; no. 2; pp. 267 - 273
• Main Authors: Peleg, Sara, Ismail, Ayesha, Uskokovic, Milan R., Avnur, Zafrira
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.02.2003
• Subjects: Animals; Caco-2 Cells; Fetus; Gene Expression Regulation - drug effects; Heterogeneous-Nuclear Ribonucleoprotein U - metabolism; Humans; Mediator Complex; Nuclear Proteins - metabolism; Osteoblasts - metabolism; osteoporosis; Rats; Receptors, Calcitriol - drug effects; Receptors, Calcitriol - genetics; Receptors, Calcitriol - metabolism; Ro-26-9228; Trans-Activators; transcription coactivators; Transcription Factors; Transcriptional Activation - drug effects; Vitamin D - analogs & derivatives; Vitamin D - pharmacology; vitamin D analogs; vitamin D receptor

Our recent studies have shown that the vitamin D analog Ro‐26‐9228 restores bone mineral density without inducing hypercalcemia in osteopenic rats. Our ex vivo experiments demonstrated that the analog upregulated gene expression in trabecular bone but not in the duodenum of female rats. We examined...