50 MHz ultrasound characterization of colitis on rats, in vitro

Ultrasound (50 MHz) was used for in vitro characterization of trinitrobenzene sulfonic acid-induced colitis on rats. Images and wave propagation parameters were obtained for colitis (n=38). Mean (plusmn2 se) results are: 1624.90(plusmn20.21) mmiddots -1 for speed of sound; 5.12(plusmn0.30) dBmiddotm...

Full description

Saved in:
Bibliographic Details
Published in2008 IEEE Ultrasonics Symposium pp. 1967 - 1970
Main Authors Soldan, M., Silva, P.C., Schanaider, A., Machado, J.C.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.11.2008
Subjects
Acoustic propagation
Attenuation
Backscatter
Colon
component
Frequency dependence
Humans
In vitro
Muscles
rat
Rats
tissue characterization
TNBS colitis
Ultrasonic imaging
ultrasound biomicroscopy
Online AccessGet full text

Cover

More Information
Summary:Ultrasound (50 MHz) was used for in vitro characterization of trinitrobenzene sulfonic acid-induced colitis on rats. Images and wave propagation parameters were obtained for colitis (n=38). Mean (plusmn2 se) results are: 1624.90(plusmn20.21) mmiddots -1 for speed of sound; 5.12(plusmn0.30) dBmiddotmm -1 for attenuation coefficient; 3.26(plusmn1.03)times10 -3 (srmiddotmm) -1 for backscattering coefficient and 1.63 (plusmn0.10) for frequency dependence. Integrated backscattering coefficient (IBC), measured across the colon wall (n=4), ranges from 10 -3 to 10 -2 (srmiddotmm) -1 , with the highest IBC values found in the submucosa layer. The result for speed of sound is similar to that of human sclera found in the literature. Results for attenuation and backscattering coefficients are in the same range of literature reports for human sclera and ciliary muscle, respectively. IBC plots allowed for ultrasound scattering quantification of the mucosa, submucosa and muscular layers for TNBS colitis.
ISBN:1424424283
9781424424283
ISSN:1051-0117
DOI:10.1109/ULTSYM.2008.0485