1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08)
A new natural product, named phomopsin A, 1‐(meta‐hydroxyphenyl)‐4‐hydroxy‐3‐isoquinolone (1), together with two known compounds cytochalasin H (2) and glucosylceramide (3), was isolated from the mangrove endophytic fungus Phomopsis sp. (ZZF08) obtained from the South China Sea coast. The structures...
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Published in | Magnetic resonance in chemistry Vol. 46; no. 5; pp. 501 - 505 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.05.2008
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Subjects | |
Online Access | Get full text |
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Summary: | A new natural product, named phomopsin A, 1‐(meta‐hydroxyphenyl)‐4‐hydroxy‐3‐isoquinolone (1), together with two known compounds cytochalasin H (2) and glucosylceramide (3), was isolated from the mangrove endophytic fungus Phomopsis sp. (ZZF08) obtained from the South China Sea coast. The structures were elucidated by 1D and 2D NMR experiments including COSY, HMQC, and HMBC. According to NMR and single‐crystal X‐ray diffraction, it was found that some assignments about 1H and 13C NMR data for cytochalasin H (2) were probably uncorrected in the previous reports. In our cytotoxicity assays, compound 1 showed moderate cytotoxicity toward KB cells with IC50 at 28.0 µg ml−1 and KBv200 cells with IC50 at 16.8 µg ml−1, and compound 2 exhibited strong cytotoxicity toward KB cells and KBv200 cells with IC50 less than 1.25 µg ml−1. Copyright © 2008 John Wiley & Sons, Ltd. |
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Bibliography: | National Natural Science Foundation of China - No. 20072058; No. 20572136 863 Foundation of China - No. 2003AA624010; No. 2006AA09Z422 istex:57A49C80765C1ED42F739F0181417F0E86A55171 ark:/67375/WNG-4C7ZL799-X Natural Science Foundation of Guangdong province, China - No. 021732 ArticleID:MRC2194 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0749-1581 1097-458X |
DOI: | 10.1002/mrc.2194 |