Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors

• Published in: Phytotherapy research Vol. 18; no. 9; pp. 729 - 736
• Main Authors: Caballero-George, C., Vanderheyden, P. M. L., Okamoto, Y., Masaki, T., Mbwambo, Z., Apers, S., Gupta, M. P., Pieters, L., Vauquelin, G., Vlietinck, A.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.09.2004; Wiley
• Subjects: Animals; AT1 receptor; Binding, Competitive - drug effects; Biological and medical sciences; CHO Cells; Cricetinae; Cricetulus; ETA receptor; Female; General pharmacology; Humans; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plants, Medicinal; Radioligand Assay; radioligand-binding; Receptor, Angiotensin, Type 1 - drug effects; Receptor, Endothelin A - drug effects; saponins; Saponins - administration & dosage; Saponins - pharmacology; triterpenes; Triterpenes - administration & dosage; Triterpenes - pharmacology; Human; Endothelin; ETA receptor; Pharmacognosy; Medicinal plant; Saponin; AT1 receptor; Renin angiotensin system; radioligand-binding; Angiotensin; Plant origin; Triterpene; triterpenes; CHO cells; Biological receptor; saponins

Different types of triterpenes including saponins and aglycons were evaluated for their ability to inhibit [3H] BQ‐123 and [3H] angiotensin II binding to the human endothelin 1 ETA and angiotensin II AT1 receptors, respectively. Selectivity for only one of the two receptors was exhibited by asiatic...