Zn(ClO4)2·6H2O as a Powerful Catalyst for a Practical Acylation of Alcohols with Acid Anhydrides

• Published in: European journal of organic chemistry Vol. 2003; no. 23; pp. 4611 - 4617
• Main Authors: Bartoli, Giuseppe, Bosco, Marcella, Dalpozzo, Renato, Marcantoni, Enrico, Massaccesi, Massimo, Sambri, Letizia
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.12.2003; WILEY‐VCH Verlag
• Subjects: Acylations; Alcohols; Anhydrides; Esters; Zinc perchlorate

A new protocol for the acylation of alcohols with anhydrides in the presence of Zn(ClO4)2·6H2O as the catalyst is reported. The activity of Zn(ClO4)2·6H2O has been proven to be superior to that exerted by dry Mg(ClO4)2 and by metal triflates. Its efficiency allows reactions between poorly reactive s...