SOLID PHASE EXTRACTION (SPE) FOR MULTI-RESIDUE ANALYSIS OF β2-AGONISTS IN BOVINE URINE
Solid phase extraction (SPE) for the treatment of bovine urine samples in the analysis of β 2 -agonist multi-residues by gas chromatography-mass spectrometry (GC-MS) was evaluated. Mabuterol, mapenterol, clenproperol, terbutaline, clenbuterol, salbutamol, clenpenterol, bromobuterol and hidroxi-metil...
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Published in | Journal of liquid chromatography & related technologies Vol. 22; no. 15; pp. 2307 - 2320 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Colchester
Taylor & Francis Group
01.01.1999
Taylor & Francis |
Subjects | |
Online Access | Get full text |
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Abstract | Solid phase extraction (SPE) for the treatment of bovine urine samples in the analysis of β
2
-agonist multi-residues by gas chromatography-mass spectrometry (GC-MS) was evaluated. Mabuterol, mapenterol, clenproperol, terbutaline, clenbuterol, salbutamol, clenpenterol, bromobuterol and hidroxi-metilclenbuterol (NA1141) were tested with five different mechanisms: adsorption, reverse phase, polar, ion exchange, and mixed phase, and eleven sorbents: diatomaceous earth, octadecyl (C
18
), octyl (C
8
), native silica (Si), diol (2OH), amine (NH
2
), trimethylaminopropyl (SAX), propylbenzenesulphonic (SCX), Bond Elut Certify® (C
8
+SCX), Clean Screen DAU® (CSDAU) and Multimode (C
18
+SCX+SAX).
Recoveries of the nine β
2
-agonists from urine samples spiked at 20 ng mL
−1
using metoprolol as internal standard were in ranges of 2.9% to 58.1%, of 12.0% to 60.7%, of 6.3% to 31.3%, of 3.3% to 56.8% and of 17.7% to 66.9%, respectively for adsorption, non polar, polar, ion exchange, and multiple extraction mechanisms. The coefficients of variation (C.V.) were also evaluated and discussed.
The proposed study show that mixed phase sorbents, especially those which combine hydrophobic and strong cationic exchange interactions, were recommended for a β
2
-agonist multi-residue solid phase extraction procedure from bovine urine. |
---|---|
AbstractList | Solid phase extraction (SPE) for the treatment of bovine urine samples in the analysis of β
2
-agonist multi-residues by gas chromatography-mass spectrometry (GC-MS) was evaluated. Mabuterol, mapenterol, clenproperol, terbutaline, clenbuterol, salbutamol, clenpenterol, bromobuterol and hidroxi-metilclenbuterol (NA1141) were tested with five different mechanisms: adsorption, reverse phase, polar, ion exchange, and mixed phase, and eleven sorbents: diatomaceous earth, octadecyl (C
18
), octyl (C
8
), native silica (Si), diol (2OH), amine (NH
2
), trimethylaminopropyl (SAX), propylbenzenesulphonic (SCX), Bond Elut Certify® (C
8
+SCX), Clean Screen DAU® (CSDAU) and Multimode (C
18
+SCX+SAX).
Recoveries of the nine β
2
-agonists from urine samples spiked at 20 ng mL
−1
using metoprolol as internal standard were in ranges of 2.9% to 58.1%, of 12.0% to 60.7%, of 6.3% to 31.3%, of 3.3% to 56.8% and of 17.7% to 66.9%, respectively for adsorption, non polar, polar, ion exchange, and multiple extraction mechanisms. The coefficients of variation (C.V.) were also evaluated and discussed.
The proposed study show that mixed phase sorbents, especially those which combine hydrophobic and strong cationic exchange interactions, were recommended for a β
2
-agonist multi-residue solid phase extraction procedure from bovine urine. |
Author | da Silveira, Maria Irene Noronha Bañobre, Maria Carmen Castilho, Maria da Conceição Ramos, Fernando |
Author_xml | – sequence: 1 givenname: Fernando surname: Ramos fullname: Ramos, Fernando organization: Universidade de Coimbra – sequence: 2 givenname: Maria Carmen surname: Bañobre fullname: Bañobre, Maria Carmen organization: Departamento de Bromatología, Facultad de Farmacia , Universidad de Santiago de Compostela, Campus Sur – sequence: 3 givenname: Maria da Conceição surname: Castilho fullname: Castilho, Maria da Conceição organization: Universidade de Coimbra – sequence: 4 givenname: Maria Irene Noronha surname: da Silveira fullname: da Silveira, Maria Irene Noronha organization: Universidade de Coimbra |
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Keywords | Solid phase extraction Biological fluid Agonist Chemical analysis Silylation β2-Adrenergic receptor β-Adrenergic receptor agonist Derivatization Veterinary medicine Sample preparation Adsorbent Ungulata Electron impact Urine Aminoalcohol Bovine Coupled method Benzene derivatives Gas chromatography Vertebrata Mammalia Multicomponent analysis Analysis method Simultaneous measurement Artiodactyla Mass spectrometry |
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Snippet | Solid phase extraction (SPE) for the treatment of bovine urine samples in the analysis of β
2
-agonist multi-residues by gas chromatography-mass spectrometry... |
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StartPage | 2307 |
SubjectTerms | Animal productions Biological and medical sciences Fundamental and applied biological sciences. Psychology Terrestrial animal productions Vertebrates |
Title | SOLID PHASE EXTRACTION (SPE) FOR MULTI-RESIDUE ANALYSIS OF β2-AGONISTS IN BOVINE URINE |
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