Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography: implications for hyperpolarized xenon MRI

Subjective and physiologic effects of 33% inhaled Xe were measured with 15O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as...

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Bibliographic Details
Published inJournal of magnetic resonance imaging Vol. 7; no. 4; p. 761
Main Authors Liotti, M, Martin, C C, Gao, J H, Roby, J W, Mayberg, H S, Zamarripa, F, Jerabek, P A, Fox, P T
Format Journal Article
LanguageEnglish
Published United States 01.07.1997
Subjects
Adult
Brain - diagnostic imaging
Cerebrovascular Circulation - drug effects
Depression, Chemical
Humans
Magnetic Resonance Imaging - methods
Male
Oxygen Radioisotopes
Photic Stimulation
Tomography, Emission-Computed
Visual Cortex - blood supply
Visual Cortex - drug effects
Visual Cortex - physiology
Water
Xenon - administration & dosage
Xenon - pharmacology
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Summary:Subjective and physiologic effects of 33% inhaled Xe were measured with 15O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air-breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.
ISSN:1053-1807
DOI:10.1002/jmri.1880070424