Production of high specific activity 195mPt-cisplatinum at South African Nuclear Energy Corporation for Phase 0 clinical trials in healthy individual subjects

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 56; no. 9-10; pp. 495 - 503
• Main Authors: Zeevaart, Jan Rijn, Wagener, Judith, Marjanovic-Painter, Biljana, Sathekge, Mike, Soni, Nischal, Zinn, Christa, Perkins, Gary, Smith, Suzanne V.
• Format: Journal Article
• Language: English
• Published: Bognor Regis Blackwell Publishing Ltd 01.07.2013; Wiley Subscription Services, Inc
• Subjects: 195mPt-cisplatinum; cisplatin; companion diagnostic; personalized medicine

Platinum agents continue to be the main chemotherapeutic agents used in the first‐line and second‐line treatments of cancer patients. It is important to fully understand the biological profile of these compounds in order to optimize the dose given to each patient. In a joint project with the Austral...