Repeatability of 31P MRSI in the human brain at 7 T with and without the nuclear Overhauser effect
An often‐employed strategy to enhance signals in 31P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the 31P data, because variation is reported in NOE enhancements. This would negate the signal‐to...
Saved in:
Published in | NMR in biomedicine Vol. 29; no. 3; pp. 256 - 263 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Blackwell Publishing Ltd
01.03.2016
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | An often‐employed strategy to enhance signals in 31P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the 31P data, because variation is reported in NOE enhancements. This would negate the signal‐to‐noise (SNR) gain it generates. We hypothesized that the variation in NOE enhancement values is not caused by the variability in NOE itself, but is attributable to measurement uncertainties in the values used to calculate the enhancement. If true, the expected increase in SNR with NOE would improve the repeatability of 31P MRS measurements. To verify this hypothesis, a repeatability study of native and NOE‐enhanced 31P MRSI was performed in the brains of seven healthy volunteers at 7 T. The repeatability coefficient (RC) and the coefficient of variation in repeated measurements (CoVrepeat) were determined for each method, and the 95% limits of agreement (LoAs) between native and NOE‐enhanced signals were calculated. The variation between the methods, defined by the LoA, is at least as great as that predicted by the RC of each method. The sources of variation in NOE enhancements were determined using variance component analysis. In the seven metabolites with a positive NOE enhancement (nine metabolite resonances assessed), CoVrepeat improved, on average, by 15%. The LoAs could be explained by the RCs of the individual methods for the majority of the metabolites, generally confirming our hypothesis. Variation in NOE enhancement was mainly attributable to the factor repeat, but between‐voxel effects were also present for phosphoethanolamine and (glycero)phosphocholine. CoVrepeat and fitting error were strongly correlated and improved with positive NOE. Our findings generally indicate that NOE enhances the signal of metabolites, improving the repeatability of metabolite measurements. Additional variability as a result of NOE was minimal. These findings encourage the use of NOE‐enhanced 31P MRSI. Copyright © 2015 John Wiley & Sons, Ltd.
A repeatability study of native and nuclear Overhauser effect (NOE)‐enhanced 31P MRS brain imaging at 7 T was performed in healthy volunteers. The results showed that variations in NOE enhancements per metabolite could almost completely be explained by the degree of repeatability of native and NOE‐enhanced 31P MRSI. The signal enhancement generated by NOE improved the relative repeatability of brain 31P MRSI, which is a favorable effect for this low signal‐to‐noise technique. |
---|---|
AbstractList | An often‐employed strategy to enhance signals in 31P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the 31P data, because variation is reported in NOE enhancements. This would negate the signal‐to‐noise (SNR) gain it generates. We hypothesized that the variation in NOE enhancement values is not caused by the variability in NOE itself, but is attributable to measurement uncertainties in the values used to calculate the enhancement. If true, the expected increase in SNR with NOE would improve the repeatability of 31P MRS measurements. To verify this hypothesis, a repeatability study of native and NOE‐enhanced 31P MRSI was performed in the brains of seven healthy volunteers at 7 T. The repeatability coefficient (RC) and the coefficient of variation in repeated measurements (CoVrepeat) were determined for each method, and the 95% limits of agreement (LoAs) between native and NOE‐enhanced signals were calculated. The variation between the methods, defined by the LoA, is at least as great as that predicted by the RC of each method. The sources of variation in NOE enhancements were determined using variance component analysis. In the seven metabolites with a positive NOE enhancement (nine metabolite resonances assessed), CoVrepeat improved, on average, by 15%. The LoAs could be explained by the RCs of the individual methods for the majority of the metabolites, generally confirming our hypothesis. Variation in NOE enhancement was mainly attributable to the factor repeat, but between‐voxel effects were also present for phosphoethanolamine and (glycero)phosphocholine. CoVrepeat and fitting error were strongly correlated and improved with positive NOE. Our findings generally indicate that NOE enhances the signal of metabolites, improving the repeatability of metabolite measurements. Additional variability as a result of NOE was minimal. These findings encourage the use of NOE‐enhanced 31P MRSI. Copyright © 2015 John Wiley & Sons, Ltd.
A repeatability study of native and nuclear Overhauser effect (NOE)‐enhanced 31P MRS brain imaging at 7 T was performed in healthy volunteers. The results showed that variations in NOE enhancements per metabolite could almost completely be explained by the degree of repeatability of native and NOE‐enhanced 31P MRSI. The signal enhancement generated by NOE improved the relative repeatability of brain 31P MRSI, which is a favorable effect for this low signal‐to‐noise technique. |
Author | Li, Shizhe Maas, Marnix C. van de Bank, Bart L. Scheenen, Tom W. J. Lagemaat, Miriam W. Sati, Pascal |
Author_xml | – sequence: 1 givenname: Miriam W. surname: Lagemaat fullname: Lagemaat, Miriam W. email: Correspondence to: M. W. Lagemaat, Department of Radiology and Nuclear Medicine (Post 766), Radboud University Medical Center, PO box 9101, 6500 HB, Nijmegen, the Netherlands. , miriamlagemaat@gmail.com organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands – sequence: 2 givenname: Bart L. surname: van de Bank fullname: van de Bank, Bart L. organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands – sequence: 3 givenname: Pascal surname: Sati fullname: Sati, Pascal organization: Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, MD, Bethesda, USA – sequence: 4 givenname: Shizhe surname: Li fullname: Li, Shizhe organization: MRS Core Facility, National Institute of Mental Health, National Institutes of Health, MD, Bethesda, USA – sequence: 5 givenname: Marnix C. surname: Maas fullname: Maas, Marnix C. organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands – sequence: 6 givenname: Tom W. J. surname: Scheenen fullname: Scheenen, Tom W. J. organization: Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands |
BookMark | eNpFkN9OwjAYxRuDiYAmPkJfYPi1Xel6qUSRhH8ixsvm29Zl1THI1onceetr-iQCGr065yS_nItfh7TKdWkJuWTQYwD8qoxXPRFKeULaDLQOWKh5i7RBSx6IMIIz0qnrFwCIQsHbJF3YjUWPsSuc39F1RgWb08nicURdSX1uad6ssKRxhfuNnqqvj88l3TqfUyzTY1k3_kiWTVJYrOjszVY5NrWtqM0ym_hzcpphUduL3-ySp7vb5eA-GM-Go8H1OHCMgQx4AiiVAp0wiCHGTIkUsygGay1iqCOpQCrRF6h4ymLFgaGOtOZZkkScp6JLgp_frSvszmwqt8JqZxiYgxqzV2MOasz0ZnLIf97V3r7_8Vi9mr4SSprn6dCM9Vw-zIcLo8Q38KppkQ |
ContentType | Journal Article |
Copyright | Copyright © 2015 John Wiley & Sons, Ltd. |
Copyright_xml | – notice: Copyright © 2015 John Wiley & Sons, Ltd. |
DBID | BSCLL |
DOI | 10.1002/nbm.3455 |
DatabaseName | Istex |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Physics |
EISSN | 1099-1492 |
EndPage | 263 |
ExternalDocumentID | NBM3455 ark_67375_WNG_L9P5QPGR_7 |
Genre | article |
GrantInformation_xml | – fundername: European Community's Seventh Framework Programme funderid: FP7/2007-2013 – fundername: European Research Council funderid: 243115 |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52V 52W 52X 53G 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAVGM AAXRX AAZKR ABCQN ABCUV ABEML ABHUG ABIJN ABPVW ABQWH ABWRO ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADBTR ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHBTC AIACR AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 DUUFO EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M65 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- P2P P2W P2X P2Z P4D PALCI Q.N Q11 QB0 QRW R.K RGB RIWAO RJQFR ROL RWI RX1 SAMSI SUPJJ SV3 UB1 V2E W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WXSBR XG1 XPP XV2 ZA5 ZZTAW ~IA ~WT AITYG HGLYW OIG |
ID | FETCH-LOGICAL-i1105-2c0a57709c10b0baf73daf8b0eeeaa49857057363a72d1b7201a98992fcc822d3 |
IEDL.DBID | DR2 |
ISSN | 0952-3480 |
IngestDate | Sat Aug 24 01:12:16 EDT 2024 Wed Jan 17 05:09:31 EST 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-i1105-2c0a57709c10b0baf73daf8b0eeeaa49857057363a72d1b7201a98992fcc822d3 |
Notes | Supporting info item European Research Council - No. 243115 ark:/67375/WNG-L9P5QPGR-7 European Community's Seventh Framework Programme - No. FP7/2007-2013 istex:E3CB08D852E5B90A3E0D0968D42E65C3AA53A83E ArticleID:NBM3455 |
OpenAccessLink | https://europepmc.org/articles/pmc4769102?pdf=render |
PageCount | 8 |
ParticipantIDs | wiley_primary_10_1002_nbm_3455_NBM3455 istex_primary_ark_67375_WNG_L9P5QPGR_7 |
PublicationCentury | 2000 |
PublicationDate | 2016-03 March 2016 |
PublicationDateYYYYMMDD | 2016-03-01 |
PublicationDate_xml | – month: 03 year: 2016 text: 2016-03 |
PublicationDecade | 2010 |
PublicationTitle | NMR in biomedicine |
PublicationTitleAlternate | NMR Biomed |
PublicationYear | 2016 |
Publisher | Blackwell Publishing Ltd |
Publisher_xml | – name: Blackwell Publishing Ltd |
References | Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat. Methods Med. Res. 1999; 8: 135-160. Kemp GJ, Meyerspeer M, Moser E. Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review. NMR Biomed. 2007; 20: 555-565. Scheenen TWJ, Klomp DWJ, Röll SA, Fütterer JJ, Barentsz JO, Heerschap A. Fast acquisition-weighted three-dimensional proton MR spectroscopic imaging of the human prostate. Magn. Reson. Med. 2004; 52: 80-88. Vikhoff-Baaz B, Starck G, Ljungberg M, Lagerstrand K, Forssell-Aronsson E, Ekholm S. Effects of k-space filtering and image interpolation on image fidelity in 1H MRSI. Magn. Reson. Imaging 2001; 19: 1227-1234. Wylezinska M, Cobbold JFL, Fitzpatrick J, McPhail MJW, Crossey MME, Thomas HC, Hajnal JV, Vennart W, Cox IJ, Taylor-Robinson SD. A comparison of single-voxel clinical in vivo hepatic 31P MR spectra acquired at 1.5 and 3.0 Tesla in health and diseased states. NMR Biomed. 2011; 24: 231-237. Tyler DJ, Emmanuel Y, Cochlin LE, Hudsmith LE, Holloway CJ, Neubauer S, Clarke K, Robson MD. Reproducibility of 31P cardiac magnetic resonance spectroscopy at 3 T. NMR Biomed. 2009; 22: 405-413. Brown TR, Stoyanova R, Greenberg T, Srinivasan R, Murphy-Boesch J. NOE enhancements and T1 relaxation times of phosphorylated metabolites in human calf muscle at 1.5 Tesla. Magn. Reson. Med. 1995; 33: 417-421. Freeman DM, Hurd R. Decoupling: theory and practice II. State of the art: in vivo applications of decoupling. NMR Biomed. 1997; 10: 381-393. Bachert-Baumann P, Ermark F, Zabel H-J, Sauter R, Semmler W, Lorenz WJ. In vivo nuclear Overhauser effect in 31P-1H double-resonance experiments in a 1.5-T whole-body MR system. Magn. Reson. Med. 1990; 15: 165-172. Remy C, Albrand JP, Benabid AL, Decorps M, Jacrot M, Riondel J, Foray MF. In vivo 31P nuclear magnetic resonance studies of T1 and T2 relaxation times in rat brain and in rat brain tumors implanted to nude mice. Magn. Reson. Med. 1987; 4: 144-152. Luyten PR, Bruntink G, Sloff FM, Vermeulen JW, van der Heijden JI, den Hollander JA, Heerschap A. Broadband proton decoupling in human 31P NMR spectroscopy. NMR Biomed. 1989; 1: 177-183. Li CW, Negendank WG, Murphy-Boesch J, Padavic-Shaller K, Brown TR. Molar quantitation of hepatic metabolites in vivo in proton-decoupled, nuclear Overhauser effect enhanced 31P NMR spectra localized by three-dimensional chemical shift imaging. NMR Biomed. 1996; 9: 141-155. Ter Voert EGW, Heijmen L, van Laarhoven HWM, Heerschap A. In vivo magnetic resonance spectroscopy of liver tumors and metastases. World J. Gastroenterol. 2011; 17: 5133-5149. Andrade CS, Otaduy MCG, Park EJ, Leite CC. Phosphorus-31 MR spectroscopy of the human brain: technical aspects and biomedical applications. Int. J. Curr. Res. Rev. 2014; 6: 41-57. Van de Bank BL, Orzada S, Smits F, Lagemaat MW, Rodgers CT, Bitz AK, Scheenen TW. Optimized 31 P MRS in the human brain at 7 T with a dedicated RF coil setup. NMR Biomed. 2015; 28: 1570-1578. Mathur-De Vré R, Maerschalk C, Delporte C. Spin-lattice relaxation times and nuclear Overhauser enhancement effect for 31P metabolites in model solutions at two frequencies: implications for in vivo spectroscopy. Magn. Reson. Imaging 1990; 8: 691-698. Lagemaat MW, Maas MC, Vos EK, Bitz AK, Orzada S, Weiland E, van Uden MJ, Kobus T, Heerschap A, Scheenen TWJ. 31P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, nuclear Overhauser effect, and spectral characterization. Magn. Reson. Med. 2014; 73: 909-920. Lei H, Zhu XH, Zhang XL, Ugurbil K, Chen W. In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experience. Magn. Reson. Med. 2003; 49: 199-205. Cloos MA, Boulant N, Luong M, Ferrand G, Giacomini E, Le Bihan D, Amadon A. kT-points: short three-dimensional tailored RF pulses for flip-angle homogenization over an extended volume. Magn. Reson. Med. 2012; 67: 72-80. Murphy-Boesch J, Stoyanova R, Srinivasan R, Willard T, Vigneron D, Nelson S, Taylor JS, Brown TR. Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers. NMR Biomed. 1993; 6: 173-180. Bartlett JW, Frost C. Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables. Ultrasound Obstet. Gynecol. 2008; 31: 466-475. Solga SF, Horska A, Clark JM, Diehl AM. Hepatic 31P magnetic resonance spectroscopy: a hepatologist's user guide. Liver Int. 2005; 25: 490-500. Argov Z, Löfberg M, Arnold DL. Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy. Muscle Nerve 2000; 23: 1316-1334. Shaka A, Keeler J, Freeman R. Evaluation of a new broadband decoupling sequence: WALTZ-16. J. Magn. Reson. 1983; 53: 313-340. Kobus T, Bitz AK, van Uden MJ, Lagemaat MW, Rothgang E, Orzada S, Heerschap A, Scheenen TWJ. In vivo 31P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility. Magn. Reson. Med. 2012; 68: 1683-1695. Edwards LM, Tyler DJ, Kemp GJ, Dwyer RM, Johnson A, Holloway CJ, Nevill AM, Clarke K. The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men. PLoS One 2012; 7: e37237, 1-11. Bottomley PA, Hardy CJ. Proton Overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T. Magn. Reson. Med. 1992; 24: 384-390. Lagemaat MW, Vos EK, Maas MC, Bitz AK, Orzada S, van Uden MJ, Kobus T, Heerschap A, Scheenen TWJ. Phosphorus magnetic resonance spectroscopic imaging at 7 T in patients with prostate cancer. Invest. Radiol. 2014; 49: 363-372. Sohlberg S, Wikström A-K, Olovsson M, Lindgren P, Axelsson O, Mulic-Lutvica A, Weis J, Wikström J. In vivo 31P-MR spectroscopy in normal pregnancy, early and late preeclampsia: a study of placental metabolism. Placenta 2014; 35: 318-323. Stehouwer BL, van der Kemp WJM, Luijten PR, van den Bosch MAAJ, Veldhuis WB, Wijnen JP, Klomp DWJ. 31P magnetic resonance spectroscopy of the breast and the influence of the menstrual cycle. Breast Cancer Res. Treat. 2014; 144: 583-589. Martin WRW. MR spectroscopy in neurodegenerative disease. Mol. Imaging Biol. 2007; 9: 196-203. Hudsmith LE, Neubauer S. Magnetic resonance spectroscopy in myocardial disease. JACC Cardiovasc. Imaging 2009; 2: 87-96. 2009; 22 1989; 1 1990; 15 2000; 23 1987; 4 1995; 33 2014; 49 2009 1983; 53 2008 2008; 31 2011; 17 1999; 8 2005; 25 1993; 6 2004; 52 2015; 28 1997; 10 2001; 19 2007; 9 2014; 35 2003; 49 1992; 24 2011; 24 2007; 20 2009; 2 2014; 144 2014; 73 2012; 68 2012; 7 2012; 67 2014; 6 1990; 8 1996; 9 |
References_xml | – volume: 33 start-page: 417 year: 1995 end-page: 421 article-title: NOE enhancements and T1 relaxation times of phosphorylated metabolites in human calf muscle at 1.5 Tesla publication-title: Magn. Reson. Med. – year: 2009 – volume: 8 start-page: 691 year: 1990 end-page: 698 article-title: Spin–lattice relaxation times and nuclear Overhauser enhancement effect for P metabolites in model solutions at two frequencies: implications for in vivo spectroscopy publication-title: Magn. Reson. Imaging – volume: 68 start-page: 1683 year: 2012 end-page: 1695 article-title: In vivo P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility publication-title: Magn. Reson. Med. – volume: 10 start-page: 381 year: 1997 end-page: 393 article-title: Decoupling: theory and practice II. State of the art: in vivo applications of decoupling publication-title: NMR Biomed. – volume: 73 start-page: 909 year: 2014 end-page: 920 article-title: P MR spectroscopic imaging of the human prostate at 7 T: T1 relaxation times, nuclear Overhauser effect, and spectral characterization publication-title: Magn. Reson. Med. – volume: 52 start-page: 80 year: 2004 end-page: 88 article-title: Fast acquisition‐weighted three‐dimensional proton MR spectroscopic imaging of the human prostate publication-title: Magn. Reson. Med. – volume: 8 start-page: 135 year: 1999 end-page: 160 article-title: Measuring agreement in method comparison studies publication-title: Stat. Methods Med. Res. – volume: 9 start-page: 196 year: 2007 end-page: 203 article-title: MR spectroscopy in neurodegenerative disease publication-title: Mol. Imaging Biol. – volume: 24 start-page: 384 year: 1992 end-page: 390 article-title: Proton Overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5 T publication-title: Magn. Reson. Med. – volume: 1 start-page: 177 year: 1989 end-page: 183 article-title: Broadband proton decoupling in human P NMR spectroscopy publication-title: NMR Biomed. – volume: 2 start-page: 87 year: 2009 end-page: 96 article-title: Magnetic resonance spectroscopy in myocardial disease publication-title: JACC Cardiovasc. Imaging – volume: 53 start-page: 313 year: 1983 end-page: 340 article-title: Evaluation of a new broadband decoupling sequence: WALTZ‐16 publication-title: J. Magn. Reson. – volume: 35 start-page: 318 year: 2014 end-page: 323 article-title: In vivo P‐MR spectroscopy in normal pregnancy, early and late preeclampsia: a study of placental metabolism publication-title: Placenta – volume: 31 start-page: 466 year: 2008 end-page: 475 article-title: Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables publication-title: Ultrasound Obstet. Gynecol. – volume: 6 start-page: 41 year: 2014 end-page: 57 article-title: Phosphorus‐31 MR spectroscopy of the human brain: technical aspects and biomedical applications publication-title: Int. J. Curr. Res. Rev. – volume: 144 start-page: 583 year: 2014 end-page: 589 article-title: P magnetic resonance spectroscopy of the breast and the influence of the menstrual cycle publication-title: Breast Cancer Res. Treat. – volume: 24 start-page: 231 year: 2011 end-page: 237 article-title: A comparison of single‐voxel clinical in vivo hepatic P MR spectra acquired at 1.5 and 3.0 Tesla in health and diseased states publication-title: NMR Biomed. – volume: 19 start-page: 1227 year: 2001 end-page: 1234 article-title: Effects of k‐space filtering and image interpolation on image fidelity in H MRSI publication-title: Magn. Reson. Imaging – volume: 9 start-page: 141 year: 1996 end-page: 155 article-title: Molar quantitation of hepatic metabolites in vivo in proton‐decoupled, nuclear Overhauser effect enhanced P NMR spectra localized by three‐dimensional chemical shift imaging publication-title: NMR Biomed. – volume: 20 start-page: 555 year: 2007 end-page: 565 article-title: Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by P MRS: a quantitative review publication-title: NMR Biomed. – volume: 17 start-page: 5133 year: 2011 end-page: 5149 article-title: In vivo magnetic resonance spectroscopy of liver tumors and metastases publication-title: World J. Gastroenterol. – year: 2008 – volume: 28 start-page: 1570 year: 2015 end-page: 1578 article-title: Optimized 31 P MRS in the human brain at 7 T with a dedicated RF coil setup publication-title: NMR Biomed. – volume: 23 start-page: 1316 year: 2000 end-page: 1334 article-title: Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy publication-title: Muscle Nerve – volume: 49 start-page: 363 year: 2014 end-page: 372 article-title: Phosphorus magnetic resonance spectroscopic imaging at 7 T in patients with prostate cancer publication-title: Invest. Radiol. – volume: 15 start-page: 165 year: 1990 end-page: 172 article-title: In vivo nuclear Overhauser effect in P– H double‐resonance experiments in a 1.5‐T whole‐body MR system publication-title: Magn. Reson. Med. – volume: 6 start-page: 173 year: 1993 end-page: 180 article-title: Proton‐decoupled P chemical shift imaging of the human brain in normal volunteers publication-title: NMR Biomed. – volume: 67 start-page: 72 year: 2012 end-page: 80 article-title: kT‐points: short three‐dimensional tailored RF pulses for flip‐angle homogenization over an extended volume publication-title: Magn. Reson. Med. – volume: 22 start-page: 405 year: 2009 end-page: 413 article-title: Reproducibility of P cardiac magnetic resonance spectroscopy at 3 T publication-title: NMR Biomed. – volume: 25 start-page: 490 year: 2005 end-page: 500 article-title: Hepatic P magnetic resonance spectroscopy: a hepatologist's user guide publication-title: Liver Int. – volume: 7 start-page: 1 year: 2012 end-page: 11 article-title: The reproducibility of 31‐phosphorus MRS measures of muscle energetics at 3 Tesla in trained men publication-title: PLoS One – volume: 49 start-page: 199 year: 2003 end-page: 205 article-title: In vivo P magnetic resonance spectroscopy of human brain at 7 T: an initial experience publication-title: Magn. Reson. Med. – volume: 4 start-page: 144 year: 1987 end-page: 152 article-title: In vivo P nuclear magnetic resonance studies of T1 and T2 relaxation times in rat brain and in rat brain tumors implanted to nude mice publication-title: Magn. Reson. Med. |
SSID | ssj0008432 |
Score | 2.182076 |
Snippet | An often‐employed strategy to enhance signals in 31P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance.... |
SourceID | wiley istex |
SourceType | Publisher |
StartPage | 256 |
SubjectTerms | 7 T MRS repeatability reproducibility ultrahigh field |
Title | Repeatability of 31P MRSI in the human brain at 7 T with and without the nuclear Overhauser effect |
URI | https://api.istex.fr/ark:/67375/WNG-L9P5QPGR-7/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fnbm.3455 |
Volume | 29 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwELYQEo-FRwHxlgfEluLYTtyMUFEeoqWUIpAYIttxRIVIUUklYGLlb_JLODtNeUyIKRku0unOZ3--3H2H0A6hkkpu4KaaGuLxkElPcaY9ohM4fJifKGK7kZut8PiKn94EN6OqStsLU_BDjBNuNjLcfm0DXKqnvW-koeqhynhg-8stj57FQ50v5qgad7PJAEBQj_EaKXlnCd0rPwQ4ai35_BOWunOlMY9uS42KcpL76jBXVf36i6zxfyovoLkR3MT7xfpYRBMmq6CZejnlrYKmm6Of6xU05apB9dMSSgCWwx5dUHi_4H6Kmd_Gzc7lCe5lGCAjdqP9sLLzJbDMsfh4e-9im9PFMkvcS3-YO8nMEibLAT6HmLmTNieCixqSZXTVOOzWj73ROAavBxgh8KgmMhCCRNon4EGZCpbItKaIMUZKHlmq_EAwcLegia8EQAsZwXWOploDDEnYCprM-plZRVgB0KhRxrWvwB6CSxBn1OiA-xEPiVlDu8418WNBuRHLwb2tQBNBfN06is-idnDRPurEAgSdwceCBQszjcHUsTV13Dpo2uf6XwU30CwoHhZlZptoMh8MzRbgjlxtuxX2CX0g0pY |
link.rule.ids | 315,786,790,1382,27955,27956,46327,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxEB6VIigXCgFUHgUfELdNvX7EWXGizxSyIYRU7QHJsr1eUVXdoLCRgFOv_Zv9JYy92fI4IU7ew6xkz3jsz-PxNwAvKTPMCI8n1dLTRPS4SazgLqGuwM2Hp4Wl4TVyPuoNjsTbE3myAq_btzANP8R1wC14Rlyvg4OHgPTWb6yh9rzLhZQ34CZ6uwxeuTv5xR3VF7E6GUIIlnDRpy3zLGVb7Z8ISIMuv_0JTOPOsr8On9o-NQklZ91Fbbvux190jf_Z6Xtwd4k4yZtmityHFV91YG2nLfTWgdv58n69A7diQqj7-gAKROa4TDcs3t_JrCQ8HZN88vGQnFYEUSOJ1f2IDSUmiKmJurq4nJIQ1iWmKuLHbFFHySpwJps5eY9u89mEsAhp0kgewtH-3nRnkCwrMiSnCBNkwhw1UimauZSiEU2peGHKvqXee2NEFtjypeJoccWK1CpEFybDEx0rnUMkUvBHsFrNKr8BxCLW6DMuXGpRH0oYFOfMOynSTPSofwyvom30l4Z1Q5v5WUhCU1Ifjw70MBvLD-ODiVYoGDV-LdgQMTONqtZB1Xq0nYf2yb8KvoC1wTQf6uHh6N1TuIOD6DVZZ89gtZ4v_CbCkNo-j9PtJ8My1rY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB4VUIELtNtWPFsfqt6yOH6sN0cKLNCy22ULKhIHy3YcgRBZtGSlllOv_Zv9JYydXVp6qjglh4nizHjsbybjbwDeU2aYER4j1cLTRLS4SazgLqEux82Hp7ml4TRyt9c6OBWfzuTZpKoynIWp-SEeEm7BM-J6HRz8Ji-2_iINtddNLqScgTl8BQuB1-7gD3VUW8TmZIggWMJFm06JZynbmj6JeDSo8vtjXBo3ls4ynE-HVNeTXDXHlW26u3_YGp825hewNMGbZLueIC_hmS8bsLAzbfPWgPnu5O96A57HclB3-wpyxOW4SNcc3j_IsCA87ZPu4OshuSwJYkYSe_sRGxpMEFMR9fvnrxMSkrrElHm8GY6rKFkGxmQzIl_QaS5MSIqQuojkNZx29k52DpJJP4bkEkGCTJijRipFM5dSNKEpFM9N0bbUe2-MyAJXvlQc7a1YnlqF2MJkGM-xwjnEITl_A7PlsPQrQCwijTbjwqUW9aGEQXHOvJMizUSL-lX4EE2jb2rODW1GV6EETUn9rbevj7K-PO7vD7RCwajwB8GahplpVLUOqta9j91wXftfwXcw39_t6KPD3ud1WMRvaNUlZxswW43GfhMxSGXfxsl2D2Ib1WU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Repeatability+of+31P+MRSI+in+the+human+brain+at+7%E2%80%89T+with+and+without+the+nuclear+Overhauser+effect&rft.jtitle=NMR+in+biomedicine&rft.au=Lagemaat%2C+Miriam+W.&rft.au=van+de+Bank%2C+Bart+L.&rft.au=Sati%2C+Pascal&rft.au=Li%2C+Shizhe&rft.date=2016-03-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0952-3480&rft.eissn=1099-1492&rft.volume=29&rft.issue=3&rft.spage=256&rft.epage=263&rft_id=info:doi/10.1002%2Fnbm.3455&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_L9P5QPGR_7 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0952-3480&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0952-3480&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0952-3480&client=summon |