Cloning and expression of a human gene encoding an N-acetylgalactosamine-α2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens

• Published in: Glycobiology (Oxford) Vol. 9; no. 11; pp. 1213 - 1224
• Main Authors: Ikehara, Yuzuru, Kojima, Naoya, Kurosawa, Nobuyuki, Kudo, Takashi, Kono, Mari, Nishihara, Shoko, Issiki, Soichiro, Morozumi, Kyoei, Itzkowitz, Steven, Tsuda, Tetsuro, Nishimura, Shin-Ichiro, Tsuji, Shuichi, Narimatsu, Hisashi
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.11.1999
• Subjects: gastric cancer; intestinal metaplasia; sialyl-Tn antigen; sialyltransferase; ST6GalNAc

The sialyl-Tn (sTn) antigen is a well known cancer-associated antigen, the expression of which is related to the prognosis of cancer patients. We aimed to isolate a human gene encoding an N-acetylgalactosamine α2,6-sialyltransferase which synthesizes sTn antigen, and to characterize the enzyme. Dege...