Pulmonary hyperpolarized 129Xe morphometry for mapping xenon gas concentrations and alveolar oxygen partial pressure: Proof-of-concept demonstration in healthy and COPD subjects
Purpose Diffusion‐weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue micro‐structure. We aimed to generate absolute xenon concentration ([Xe]) and alveolar oxygen partial pressure (pAO2) maps by extracting the unrest...
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| Published in | Magnetic resonance in medicine Vol. 74; no. 6; pp. 1726 - 1732 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Blackwell Publishing Ltd
01.12.2015
Wiley Subscription Services, Inc |
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| Online Access | Get full text |
| ISSN | 0740-3194 1522-2594 |
| DOI | 10.1002/mrm.25550 |
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| Abstract | Purpose
Diffusion‐weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue micro‐structure. We aimed to generate absolute xenon concentration ([Xe]) and alveolar oxygen partial pressure (pAO2) maps by extracting the unrestricted diffusion coefficient (D0) of xenon as a morphometric parameter.
Methods
In this proof‐of‐concept demonstration, morphometry was performed using multi b‐value (0, 12, 20, 30 s/cm2) DW hyperpolarized 129Xe images obtained in four never‐smokers and four COPD ex‐smokers. Morphometric parameters and D0 maps were computed and the latter used to generate [Xe] and pAO2 maps. Xenon concentration phantoms estimating a range of values mimicking those observed in vivo were also investigated.
Results
Xenon D0 was significantly increased (P = 0.035) in COPD (0.14 ± 0.03 cm2/s) compared with never‐smokers (0.12 ± 0.02 cm2/s). COPD ex‐smokers also had significantly decreased [Xe] (COPD = 8 ± 7% versus never‐smokers = 13 ± 8%, P = 0.012) and increased pAO2 (COPD = 18 ± 3% versus never‐smokers = 15 ± 3%, P = 0.009) compared with never‐smokers. Phantom measurements showed the expected dependence of D0 on [Xe] over the range of concentrations anticipated in vivo.
Conclusion
DW hyperpolarized 129Xe MRI morphometry can be used to simultaneously map [Xe] and pAO2 in addition to providing micro‐structural biomarkers of emphysematous destruction in COPD. Phantom measurements of D0([Xe]) supported the hypotheses that differences in subjects may reflect differences in functional residual capacity. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. Magn Reson Med 74:1726–1732, 2015. © 2014 Wiley Periodicals, Inc. |
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| AbstractList | Purpose
Diffusion‐weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue micro‐structure. We aimed to generate absolute xenon concentration ([Xe]) and alveolar oxygen partial pressure (pAO2) maps by extracting the unrestricted diffusion coefficient (D0) of xenon as a morphometric parameter.
Methods
In this proof‐of‐concept demonstration, morphometry was performed using multi b‐value (0, 12, 20, 30 s/cm2) DW hyperpolarized 129Xe images obtained in four never‐smokers and four COPD ex‐smokers. Morphometric parameters and D0 maps were computed and the latter used to generate [Xe] and pAO2 maps. Xenon concentration phantoms estimating a range of values mimicking those observed in vivo were also investigated.
Results
Xenon D0 was significantly increased (P = 0.035) in COPD (0.14 ± 0.03 cm2/s) compared with never‐smokers (0.12 ± 0.02 cm2/s). COPD ex‐smokers also had significantly decreased [Xe] (COPD = 8 ± 7% versus never‐smokers = 13 ± 8%, P = 0.012) and increased pAO2 (COPD = 18 ± 3% versus never‐smokers = 15 ± 3%, P = 0.009) compared with never‐smokers. Phantom measurements showed the expected dependence of D0 on [Xe] over the range of concentrations anticipated in vivo.
Conclusion
DW hyperpolarized 129Xe MRI morphometry can be used to simultaneously map [Xe] and pAO2 in addition to providing micro‐structural biomarkers of emphysematous destruction in COPD. Phantom measurements of D0([Xe]) supported the hypotheses that differences in subjects may reflect differences in functional residual capacity. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. Magn Reson Med 74:1726–1732, 2015. © 2014 Wiley Periodicals, Inc. Purpose Diffusion-weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue micro-structure. We aimed to generate absolute xenon concentration ([Xe]) and alveolar oxygen partial pressure (pAO2) maps by extracting the unrestricted diffusion coefficient (D0) of xenon as a morphometric parameter. Methods In this proof-of-concept demonstration, morphometry was performed using multi b-value (0, 12, 20, 30 s/cm2) DW hyperpolarized 129Xe images obtained in four never-smokers and four COPD ex-smokers. Morphometric parameters and D0 maps were computed and the latter used to generate [Xe] and pAO2 maps. Xenon concentration phantoms estimating a range of values mimicking those observed in vivo were also investigated. Results Xenon D0 was significantly increased (P=0.035) in COPD (0.14±0.03 cm2/s) compared with never-smokers (0.12±0.02 cm2/s). COPD ex-smokers also had significantly decreased [Xe] (COPD=8±7% versus never-smokers= 13±8%, P=0.012) and increased pAO2 (COPD=18±3% versus never-smokers=15±3%, P=0.009) compared with never-smokers. Phantom measurements showed the expected dependence of D0 on [Xe] over the range of concentrations anticipated in vivo. Conclusion DW hyperpolarized 129Xe MRI morphometry can be used to simultaneously map [Xe] and pAO2 in addition to providing micro-structural biomarkers of emphysematous destruction in COPD. Phantom measurements of D0([Xe]) supported the hypotheses that differences in subjects may reflect differences in functional residual capacity. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. Magn Reson Med 74:1726-1732, 2015. © 2014 Wiley Periodicals, Inc. |
| Author | Farag, A. Parraga, G. Ouriadov, A. Kirby, M. McCormack, D.G. Santyr, G.E. |
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| References_xml | – reference: Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-338. – reference: Marshall H, Parra-Robles J, Deppe MH, Lipson DA, Lawson R, Wild JM. 3He pO2 mapping is limited by delayed-ventilation and diffusion in chronic obstructive pulmonary disease. Magn Reson Med 2014;71:1172-1178. – reference: Nikolaou P, Coffey AM, Walkup LL, et al. Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A 2013;110:14150-14155. – reference: Kaushik SS, Cleveland ZI, Cofer GP, et al. Diffusion weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011;65:1155-1165. – reference: Ouriadov A, Farag A, Kirby M, McCormack DG, Parraga G, Santyr GE. Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease. Magn Reson Med 2013;70:1699-1706. – reference: Mugler JP, Altes TA. Hyperpolarized 129Xe MRI of the human lung. J Magn Reson Imaging 2013;37:313-331. – reference: Möller HE, Chen XJ, Saam B, Hagspiel KD, Johnson GA, Altes TA, de Lange EE, Kauczor HU. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 2002;47:1029-1051. – reference: Chen XJ, Moller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, Johnson GA. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med 1999;42:721-728. – reference: Miller GW, Altes TA, Brookeman JR, de Lange EE, Mugler JP III. Hyperpolarized 3He lung ventilation imaging with B1-inhomogeneity correction in a single breath-hold scan. MAGMA 2004;16:218-226. – reference: Hersman FW, Ruset IC, Ketel S, et al. Large production system for hyperpolarized 129Xe for human lung imaging studies. Acad Radiol 2008;15:683-692. – reference: Kirby M, Svenningsen S, Owrangi A, et al. Hyperpolarized helium-3 and xenon-129 magnetic resonance imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. Radiology 2012;265:600-610. – reference: Yablonskiy DA, Sukstanskii AL, Leeawoods JC, Gierada DS, Bretthorst GL, Lefrak SS, Cooper JD, Conradi MS. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion. Proc Natl Acad Sci U S A 2002;99:3111-3116. – reference: Quirk JD, Lutey BA, Gierada DS, Woods JC, Senior RM, Lefrak SS, Sukstanskii AL, Conradi MS, Yablonskiy DA. In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry. Radiology 2011;260:866-874. – reference: Yablonskiy DA, Sukstanskii AL, Quirk JD, Woods JC, Conradi MS. Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results. Magn Reson Med 2014;71:486-505. – reference: Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS Jr, Wishnia A. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature 1994;370:199-201. – reference: Sukstanskii AL, Yablonskiy DA. Lung morphometry with hyperpolarized 129Xe: theoretical background. Magn Reson Med 2012;67:856-866. – volume: 15 start-page: 683 year: 2008 end-page: 692 article-title: Large production system for hyperpolarized 129Xe for human lung imaging studies publication-title: Acad Radiol – volume: 260 start-page: 866 year: 2011 end-page: 874 article-title: In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry publication-title: Radiology – volume: 265 start-page: 600 year: 2012 end-page: 610 article-title: Hyperpolarized helium‐3 and xenon‐129 magnetic resonance imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease publication-title: Radiology – volume: 16 start-page: 218 year: 2004 end-page: 226 article-title: Hyperpolarized 3He lung ventilation imaging with B1‐inhomogeneity correction in a single breath‐hold scan publication-title: MAGMA – volume: 65 start-page: 1155 year: 2011 end-page: 1165 article-title: Diffusion weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease publication-title: Magn Reson Med – volume: 26 start-page: 319 year: 2005 end-page: 338 article-title: Standardisation of spirometry publication-title: Eur Respir J – volume: 370 start-page: 199 year: 1994 end-page: 201 article-title: Biological magnetic resonance imaging using laser‐polarized 129Xe publication-title: Nature – volume: 99 start-page: 3111 year: 2002 end-page: 3116 article-title: Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion publication-title: Proc Natl Acad Sci U S A – volume: 47 start-page: 1029 year: 2002 end-page: 1051 article-title: MRI of the lungs using hyperpolarized noble gases publication-title: Magn Reson Med – volume: 110 start-page: 14150 year: 2013 end-page: 14155 article-title: Near‐unity nuclear polarization with an open‐source 129Xe hyperpolarizer for NMR and MRI publication-title: Proc Natl Acad Sci U S A – year: 2005 – volume: 71 start-page: 486 year: 2014 end-page: 505 article-title: Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results publication-title: Magn Reson Med – volume: 70 start-page: 1699 year: 2013 end-page: 1706 article-title: Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease publication-title: Magn Reson Med – year: 2008 – volume: 42 start-page: 721 year: 1999 end-page: 728 article-title: Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo publication-title: Part I: diffusion coefficient. 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Diffusion‐weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue... Purpose Diffusion-weighted (DW) hyperpolarized 129Xe morphometry magnetic resonance imaging (MRI) can be used to map regional differences in lung tissue... |
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| Title | Pulmonary hyperpolarized 129Xe morphometry for mapping xenon gas concentrations and alveolar oxygen partial pressure: Proof-of-concept demonstration in healthy and COPD subjects |
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