Different Molecular Mechanisms of Vitamin D3 Receptor Antagonists

• Published in: Molecular pharmacology Vol. 59; no. 6; p. 1478
• Main Authors: Andrea Toell, Manuel Macias Gonzalez, Dagmar Ruf, Andreas Steinmeyer, Seiichi Ishizuka, Carsten Carlberg
• Format: Journal Article
• Language: English
• Published: American Society for Pharmacology and Experimental Therapeutics 01.06.2001

Two structurally different antagonists of the nuclear hormone 1α,25-dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ], the 25-carboxylic ester ZK159222 and the 26,23-lactone TEI-9647, have recently been described. In this study, the molecular mechanisms and the efficacy of both antagonists were compared. ZK...