A Major Lung CD103 ({alpha}E)-beta7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins

• Published in: The Journal of immunology (1950) Vol. 176; no. 4; pp. 2161 - 2172
• Main Authors: Sung, Sun-Sang J, Fu, Shu Man, Rose, C. Edward, Jr, Gaskin, Felicia, Ju, Shyr-Te, Beaty, Steven R
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.02.2006
• Subjects: Animals; Antigens, CD - metabolism; Antigens, Surface - genetics; Antigens, Surface - metabolism; B7-1 Antigen - metabolism; B7-H1 Antigen; Biomarkers; CD11b Antigen - metabolism; Cell Adhesion; Cell Proliferation; Cells, Cultured; Claudin-1; Claudins; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - metabolism; Epithelial Cells - immunology; Epithelial Cells - metabolism; Gene Expression Regulation; Inflammation - metabolism; Integrin alpha Chains - metabolism; Integrin beta Chains - metabolism; Interleukin-12 - biosynthesis; Lectins - metabolism; Lectins, C-Type - genetics; Lectins, C-Type - metabolism; Lung - cytology; Lung - immunology; Macrophages - metabolism; Mannose-Binding Lectins - genetics; Mannose-Binding Lectins - metabolism; Membrane Glycoproteins - metabolism; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Peptides - metabolism; Sialic Acid Binding Immunoglobulin-like Lectins; T-Lymphocytes - cytology; Tight Junctions - metabolism; Zonula Occludens-2 Protein

Dendritic cells (DC) mediate airway Ag presentation and play key roles in asthma and infections. Although DC subsets are known to perform different functions, their occurrence in mouse lungs has not been clearly defined. In this study, three major lung DC populations have been found. Two of them are...