The Radiotoxicity of 131I Therapy of Thyroid Cancer: Assessment by Micronucleus Assay of B Lymphocytes

• Published in: The Journal of nuclear medicine (1978) Vol. 45; no. 4; p. 608
• Main Authors: Watanabe, Naoto, Kanegane, Hirokazu, Kinuya, Seigo, Shuke, Noriyuki, Yokoyama, Kunihiko, Kato, Hiroshi, Tomizawa, Gakuto, Shimizu, Masashi, Funada, Hisashi, Seto, Hikaru
• Format: Journal Article
• Language: English
• Published: United States Soc Nuclear Med 01.04.2004
• Subjects: Adult; Aged; B-Lymphocytes - pathology; B-Lymphocytes - radiation effects; Chromosome Aberrations; Chromosomes - radiation effects; Female; Humans; Iodine Radioisotopes - adverse effects; Iodine Radioisotopes - therapeutic use; Male; Micronucleus Tests; Middle Aged; Radiation Injuries - etiology; Radiation Injuries - genetics; Radiopharmaceuticals - adverse effects; Radiopharmaceuticals - therapeutic use; Radiotherapy - adverse effects; Thyroid Gland - pathology; Thyroid Gland - radiation effects; Thyroid Neoplasms - blood; Thyroid Neoplasms - pathology; Thyroid Neoplasms - radiotherapy

We investigated cytologic radiation damage in thyroid cancer after (131)I therapy using micronucleus assay (MNA) of B lymphocytes exclusively, as opposed to our previous study in which MNA of all lymphocyte subsets was used. We studied 22 thyroid cancer patients treated with 3.7 GBq of (131)I. Perip...